Cal Poly Cartilage Biomechanics Group

P.I. Stephen M. Klisch, Ph.D.

melogo
calpolylogo
3DACpic
UCC-2 discs

Links to an abstract page and a pdf file for a manuscript appears immediately following the reference, when applicable. The pdf files are published on the Cal Poly Digital Commons website. Copyright permissions have been obtained from the copyright owners.

Journal Articles

  1. Thomas GC, Asanbaeva A, Vena P, Sah RL, Klisch SM.  A nonlinear constituent based viscoelastic model for articular cartilage and analysis of tissue remodeling due to altered glycosaminoglycan-collagen interactions. Journal of Biomechanical Engineering, 131:101002, 2009.ABSTRACT PDF
  2. Ficklin TP, Davol A, Klisch SM. Simulating the growth of articular cartilage explants in a permeation bioreactor to aid in experimental protocol design. Journal of Biomechanical Engineering, 131:041008, 2009.ABSTRACT PDF
  3. Asanbaeva A, Tam J, Schumacher BL, Klisch SM, Masuda K, Sah RL. Articular cartilage tensile integrity: modulation by matrix depletion is maturation-dependent. Archives of Biochemistry and Biophysics, 474:175-182, 2008.ABSTRACT PDF
  4. Klisch SM, Asanbaeva A, Oungoulian SR, Masuda K, Thonar EJ, Davol A, Sah RL. A cartilage growth mixture model with collagen remodeling: validation protocols. Journal of Biomechanical Engineering, 130:031006, 2008.ABSTRACT PDF
  5. Williams GM, Klisch SM, Sah RL. Bioengineering cartilage growth, maturation, and form. Pediatric Research, 63:527-534 2008.ABSTRACT
  6. Asanbaeva A, Masuda K, Thonar EJ, Klisch SM, Sah RL. Cartilage growth and remodeling: modulation of balance between proteoglycan and collagen network in vitro with beta-aminopropionitrile. Osteoarthritis and Cartilage, 16:1-11, 2008.ABSTRACT
  7. Davol A, Bingham MS, Sah RL, Klisch SM. A nonlinear finite element model of cartilage growth. Biomechanics and Modeling in Mechanobiology, 7:295-307, 2008.ABSTRACT PDF
  8. Asanbaeva A, Masuda K, Thonar EJ, Klisch SM, Sah RL. Regulation of immature cartilage growth by IGF-1, TGF-b1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network. Biomechanics and Modeling in Mechanobiology, 7:263-276, 2008.ABSTRACT
  9. Ficklin T, Thomas G, Barthel JC, Thonar EJ, Masuda K, Asanbaeva A, Chen AC, Sah RL, Davol A, Klisch SM. Articular cartilage mechanical and biochemical property relations before and after in vitro growth. Journal of Biomechanics, 40:3607-3614, 2007.ABSTRACT PDF
  10. Klisch SM. Bimodular polyconvex fiber-reinforced strain energy functions for articular cartilage. ASME Journal of Biomechanical Engineering, 129: 250-258, 2007.ABSTRACT PDF
  11. Asanbaeva A, Masuda K, Thonar EJ, Klisch SM, Sah RL. Mechanisms of cartilage growth: modulation of balance between proteoglycan and collagen in vitro using chondroitinase ABC. Arthritis and Rheumatism, 56(1): 188-198, 2007.
  12. Klisch SM. A bimodular theory for finite deformations: comparison of orthotropic second-order and exponential stress constitutive equations for articular cartilage. Biomechanics and Modeling in Mechanobiology, 5:90-101, 2006.ABSTRACT PDF
  13. Klisch SM, Sah RL, Hoger A. A cartilage growth mixture model for infinitesimal strains: solutions of boundary-value problems related to in vitro growth experiments. Biomechanics and Modeling in Mechanobiology 3: 209-223, 2005.ABSTRACT PDF
  14. Klisch SM, Chen SS, Hoger A, Sah RL.  A growth mixture theory for cartilage with application to growth-related experiments on cartilage explants.  ASME Journal of Biomechanical Engineering 125: 169-179, 2003.ABSTRACT PDF
  15. Klisch SM, Hoger A.  Volumetric growth of thermoelastic materials and mixtures. Mathematics and Mechanics of Solids 8:377-402, 2003.ABSTRACT PDF
  16. Klisch SM.  A mixture of elastic materials with different constituent temperatures and internal constraints. International Journal of Engineering Science 40(7): 805-828, 2001.ABSTRACT PDF
  17. Klisch SM, Van Dyke TJ, Hoger A.  A theory of volumetric growth for compressible elastic biological materials. Mathematics and Mechanics of Solids 6:551-575, 2001.ABSTRACT PDF
  18. Klisch SM, Lotz JC.  A special theory of biphasic mixtures and experimental results for human annulus fibrosus tested in confined compression. ASME Journal of Biomechanical Engineering 122: 180-188, 2000.ABSTRACT PDF
  19. Klisch SM.  Internally constrained mixtures of elastic continua. Mathematics and Mechanics of Solids 4: 481-498, 1999.ABSTRACT PDF
  20. Klisch SM, Lotz JC.  Application of a fiber-reinforced continuum theory to multiple deformations of the annulus fibrosus. Journal of Biomechanics 32: 1027-1036, 1999.ABSTRACT PDF
  21. Whyne C, Hu SS, Klisch SM, Lotz JC.  Effect of the pedicle and posterior arch on vertebral body strength predictions in finite element modeling. Spine 23(8): 899-907, 1998.
  22. Glazer PA, Colliou O, Klisch SM, Bradford DS, Bueff HU, Lotz JC.  Biomechanical analysis of multi-level fixation methods in the lumbar spine.  Spine 22(2): 171-182, 1997.
  23. Hall G, Crandall J, Klisch S, Klopp G, Pilkey W. Measurement of dynamic rotary motion using magnetohydrodynamic angular rate sensors.  Shock and Vibration Digest 28(5): 12-17, 1996.

Book Chapters

  1. Klisch SM. Continuum Models of growth with special emphasis on articular cartilage. In: Mechanics of Biological Tissue. Eds. Holzapfel GA, Ogden RW, Springer, Berlin-Heidelberg-New York, 2006.
  2. Chen AC, Klisch SM, Bae WC, Temple MM, McGowan KB, Gratz KR, Schumacher BL, Sah RL. Mechanical characterization of native and tissue-engineered cartilage. In: Cartilage and osteoarthritis. Eds. Sabatini M, Pastoureau P. 101 Humana Press, Totowa, NJ.
  3. Klisch SM, DiMicco MA, Hoger A, and Sah RL.  Bioengineering the growth of articular cartilage.  In: Functional tissue engineering: the role of biomechanics. Eds. Guilak F, Butler D, Mooney D, Goldstein S. Springer-Verlag, 2003.

Conference Abstracts

  1. Van Donk JR, Dills KJ, Williams GM, Smith SA, Chen AC, Raub C, Hazelwod SJ, Sah RL, Klisch SM. Regulation of articular cartilage volume and compressive properties by sequential application of IGF-1 and TGF-β1 during in vitro growth. Transactions of the 2009 BMES Annual Fall Meeting, 2009.
  2. Pho GN, Yamauchi KA, Williams GM, Raub CB, Smith SA, Hazelwod SJ, Klisch SM, Sah RL. Differential regulation of articular cartilage dimensional growth in vitro by dynamic compression and growth factors in combination. Transactions of the 2009 BMES Annual Fall Meeting, 2009.
  3. Stender ME, Flores CR, Dills KJ, Williams GM, Stewart KM, Hazelwood S, Chen AC, Sah RL, Klisch SM.  Differential regulation of articular cartilage biomechanical and biochemical properties by IGF-I and TGF-β1 during in vitro growth. Transactions of the ASME Summer Bioengineering Conference, 2009.
  4. Klisch SM, Thomas GC, Asanbaeva A, Vena P, Sah RL.  Nonlinear constituent based viscoelastic modeling of GAG depletion experiments suggests strong GAG-collagen interactions in immature articular cartilage tissue. Transactions of the ASME Summer Bioengineering Conference, 2009.
  5. Stender ME, Dills KJ, Nelson LM, Williams GM, Stewart KM, Flores CR, Chen AC, Sah RL, Klisch SM. Differential regulation of articular cartilage compressive properties by IGF-I and TGF-b1 during in vitro growth. Transactions of the 2008 BMES Annual Fall Meeting, 2008.
  6. Oungoulian SR, Klisch SM. A cartilage growth mixture model validation for grown articular cartilage tested in compression, Transactions of the 2008 BMES Annual Fall Meeting, 2008.
  7. Klisch SM, Thomas GC, Hendrickson K. Analytical and experimental study of articular cartilage growth in vitro. 2007 NSF Grantee Conference on International Research and Education in Engineering, 2007.
  8. Thomas GC, Ficklin TP, Barthel JC, Asanbaeva A, Thonar EJ, Masuda K, Chen AC, Sah RL, Davol A, Klisch SM.  Investigation of cartilage biomechanical properties: dependence on strain, direction, and biochemical composition. Transactions of the ASME Summer Bioengineering Conference, 2007.
  9. Oungoulian SR, Chen SS, Davol A, Sah RL, Klisch SM.  Extended two compartmental swelling stress model and isotropic Cauchy stress equation for articular cartilage proteoglycans. Transactions of the ASME Summer Bioengineering Conference, 2007.
  10. Klisch SM, Asanbaeva A, Oungoulian SR, Thonar EJ, Masuda K, Davol A, Sah RL. A cartilage growth mixture model with collagen remodeling: validation protocols. Transactions of the ASME Summer Bioengineering Conference, 2007.
  11. Asanbaeva A, Schumacher BL, Klisch SM, Masuda K, Sah RL. Articular cartilage tensile integrity: modulation by matrix depletion is maturation-dependent. Transactions of the Annual Meeting of the Orthopaedic Research Society, 2007.
  12. Ficklin TP, Thomas GC, Asanbaeva A, Chen AC, Sah RL, Davol A, Klisch SM.  Development of an experimental protocol to measure anisotropic material properties of bovine articular cartilage. Transactions of the ASME Summer Bioengineering Conference, 2006.
  13. Klisch SM, Sah RL, Davol A. Bimodular-orthotropic-polyconvex strain energy functions for the collagen-proteoglycan solid matrix of articular cartilage. Transactions of the ASME Summer Bioengineering Conference, 2006.
  14. Klisch SM, Asanbaeva A, Sah RL, Davol A. Theoretical and experimental study of articular cartilage growth. U.S. National Congress of Theoretical and Applied Mechanics, 2006.
  15. Klisch SM, Sah RL, Davol A. A bimodular theory for finite deformations: comparison of orthotropic second-order and exponential stress constitutive equations for articular cartilage. International Conference on the Mechanics of Biological Tissue, 2005.
  16. Davol A, Sah RL, Klisch SM. A cartilage growth finite element model for simulation of in vitro unconfined compression tests. International Conference on the Mechanics of Biological Tissue, 2005.
  17. Bingham, MS, Davol A, Sah RL, Klisch SM. A nonlinear finite element model of cartilage growth under in vitro dynamic compression. Transactions of the ASME Summer Bioengineering Conference, 2005.
  18. Asanbaeva A, Masuda K, Thonar EJ, Klisch SM, Sah RL. Regulation of immature cartilage growth by IGF-1, TGF-b1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network. Transactions of the Annual Meeting of the Orthopaedic Research Society, 2005.
  19. Klisch, SM, Asanbaeva A, Davol A, Sah RL. Cartilage growth mixture model: finite strain theory, constitutive equations, and boundary-value problem solutions. Proceedings of the International Plasticity Meeting, 2005.
  20. Klisch SM, Holtrichter SE, Sah RL, Davol A. A bimodular second order orthotropic stress constitutive equation for cartilage. Transactions of the ASME IMECE: Advances in Bioengineering, 2004.
  21. Asanbaeva A, Masuda K, Thonar EJ, Klisch SM, Sah RL. Biophysical basis of cartilage growth: matrix remodeling. National Meeting of the American Society for Matrix Biology, 2004.
  22. Klisch SM. A bimodular second order constitutive theory for fiber-reinforced soft biological tissues. Proceedings of the IUTAM Mechanics of Biological Tissue Symposium, 2004.
  23. Asanbaeva A, McGowan KB, Masuda K, Klisch SM, Thonar EJ, Sah RL. Mechanisms of cartilage growth: alteration of function and composition in vitro by deposition of collagen and proteoglycan matrix components. Transactions of the International Cartilage Repair Society Symposium, 2004.
  24. Asanbaeva A, McGowan KB, Masuda K, Klisch SM, Thonar EJ, Sah RL. Mechanisms of cartilage growth: alteration of function and composition in vitro by deposition of collagen and proteoglycan matrix components. Transactions of the Annual Meeting of the Orthopaedic Research Society, 2004.
  25. Klisch SM, Sah RL, Hoger A: A Cartilage Growth Mixture Model for Infinitesimal Strains: Equilibrium Solutions. Transactions of the ASME Summer Bioengineering Conference, 2003.
  26. Klisch SM, Chen SS, Hoger A, and Sah RL.  A growth and remodeling mixture model and the biomechanics of developing bovine articular cartilage.  Proceedings of the Biomedical Engineering Society Annual Meeting, 2002.
  27. Klisch SM, Chen SS, Masuda K, Thonar EJ, Hoger A, and Sah RL.  Application of a growth and remodeling mixture theory to developing articular cartilage. Transactions of the  Annual Meeting of the Orthopaedic Research Society, 2001.
  28. Klisch SM, Sah RL, and Hoger A.  A growth mixture theory for cartilage. Mechanics in Biology, Eds. J Casey and G Bao. ASME AMD-Vol. 242, 2000.ABSTRACT PDF
  29. Klisch SM and Hoger A.  Development of a growth mixture theory for cartilage.  Proceedings of the International Congress of Theoretical and Applied Mechanics, 2000.
  30. Klisch SM, Sah RL, and Hoger A.  A mixture theory for the growth of cartilaginous tissues:  the solid matrix. Proceedings of the UC Bioengineering Symposium, UC Davis, 2000.
  31. Klisch SM.  A mixture of elastic materials with internal constraints. Finite Thermoelasticity, Eds. J Casey and A Abeyaratne.  ASME AMD-Vol. 236, 1999.
  32. Klisch SM and Lotz JC.  Material constants for human annulus fibrosus depend on water content and reference configuration. Transactions of the ASME: Advances in Bioengineering, 1999.
  33. Wagner, DR, Klisch SM and Lotz JC.  A constitutive formulation which simultaneously predicts the response of the annulus fibrosus to seven distinct deformations.  Proceedings of the Summer Bioengineering Conference, ASME, 1999.
  34. Klisch SM and Lotz JC.  Application of a special theory of biphasic mixtures to annulus fibrosus. Transactions of the ASME: Advances in Bioengineering, 1998.
  35. Klisch SM and Lotz JC.  Application of fiber-reinforced continuum theory to multiple deformations of the annulus fibrosus. Transactions of the ASME: Advances in Bioengineering, 1998.
  36. Klisch SM and Lotz JC.  A fiber-reinforced continuum theory and constitutive equation for the annulus fibrosus.  Transactions of the 1998 Annual Meeting of the Orthopaedic Research Society, 1998.
  37. Klisch SM and Lotz JC.  Deriving constitutive equations for a simple incompressible mixture of an elastic solid and an inviscid fluid.  Proceedings of the Summer Bioengineering Conference, ASME, 1997.
  38. Klisch SM, Duncan NA, Keaveny TM and Lotz JC.  The relative effects of disc water content and bone modulus on vertebral body stresses.  International Society for the Study of the Lumbar Spine, 1996.
  39. Glazer PA, Colliou O, Klisch SM, Bradford DS, Bueff HU and Lotz JC.  Biomechanical analysis of multi-level interbody fixation devices in the lumbar spine.  International Society for the Study of the Lumbar Spine, 1996.
  40. Whyne C, Hu S, Klisch S and Lotz J.  Effect of the pedicle on vertebral body strength predictions in finite element modeling.  International Society for the Study of the Lumbar Spine, 1996.
  41. Hall G, Crandall J, Klopp G, Klisch S, and Pilkey, W. Joint kinematics with angular rate sensors.  Proceedings of the 69th Shock and Vibration Symposium, 1996.
  42. Crandall JR, Klisch SM, Klopp GS, Sieveka E, Pilkey WD and Martin P.  Research program to investigate lower extremity injuries.  SAE International Congress and Exposition, SAE Technical Paper #940711, 1994.
  43. Crandall JR, Klopp GS, Klisch S, Kennett KB, Morgan RM and Eppinger RH. Instrumentation package for the lower extremities.  Proceedings of the International Workshop on Human Subjects for Biomechanical Research, 1994.
  44. Digges K, Malliaris A, Ommaya A, and Klisch S.  The mechanics and biomechanics of rollover casualties.  Injury Prevention Through Biomechanics Symposium, Center for Disease Control, 1992.
  45. Digges K and Klisch S.  Analysis of the factors which influence rollover crash severity. Proceedings of the International Conference on Experimental Safety Vehicles, 1991.
fearesults

© 2008 Stephen M. Klisch | Mechanical Engineering

College of Engineering | Cal Poly San Luis Obispo