Deadline Note

All unsolicited proposals directed to CMMI must be submitted during one of two annual unsolicited proposal submission windows, January 15 through February 15 and September 1 through October 1.

Synopsis

The Solid Mechanics and Materials Engineering (SMME) program links the expertise of analytical, computational and experimental solid mechanics and biomechanics with materials and surface engineering to understand, characterize, analyze, design and control the mechanical properties and performance of materials and devices. The program supports research into deformation, fracture, fatigue, friction, wear and corrosion of all types of materials, including composites, nano-structured materials, coatings and surface modification for service under extreme conditions. The program also supports experimental and analytical investigations and simulation modeling of material microstructures and their connections to nano-, meso- and macro-scale structural behavior.

Deadline Note

Full proposals can be submitted from September 1, 2009 to October 1, 2009 and from January 15, 2010 to February 15, 2010.

Synopsis

This program supports innovative research on the theories of dynamical systems, including new analytical and computational tools, as well as the novel application of dynamical systems to engineered systems.

Deadline Note

Proposals will be accepted within a window of one month before the deadline date.

Synopsis

The CIS program supports research leading to the intelligent engineering of distributed infrastructure systems.

Deadline Note

Proposals will be accepted from September 1, 2009 to October 1, 2009 and January 15, 2010 - February 15, 2010.

Synopsis

The SSS program supports research on methods to acquire and use sensor data on civil, mechanical, and manufacturing systems.

Deadline Note

Proposals may be submitted from September 1, 2009 to October 1, 2009 and from to January 15, 2010 to February 15, 2010.

Synopsis

The GEOMM program supports fundemental research on the mechanics and engineering properties of geologic materials including the mechanical properties of soil and rock, mechanically stabilized and biologically modified soil, and on natural processes, such as hydraulic, biological and thermal, that affect the behavior of these materials.

Deadline Note

The window for submission of proposals is September 1, 2009 to October 1, 2009 and January 15, 2010 to February 15, 2010.

Synopsis

The OR program supports research leading to advances in the science of models and algorithms that are applicable to the operation and optimization of large-scale systems.

Deadline Note

The window for submission of proposals is September 1, 2009 to October 1, 2009 and January 15, 2010 to February 15, 2010.

Synopsis

The SMM program supports fundamental research on the behavior of civil infrastructure materials and the mechanics of structural components in the built environment.

Deadline Note

Full proposals should be submitted from September 1, 2009 to October 1, 2009 and from January 15, 2010 - February 15, 2010.

Synopsis

The CS program supports innovative research on control theory and control technology driven by real life applications.

Deadline Note

Proposals may be submitted from September 1, 2009 to October 1, 2009 and January 15, 2010 to February 15, 2010.

Synopsis

The HMSE program supports fundamental research on the design and performance of structural systems and on new technologies for improving the behavior, safety, and reliability of structural systems and their resistance to natural hazards such as earthquakes and technological hazards (such as bombs).

Deadline Note

Proposals may be submitted from September 1, 2010 to October 1, 2010 and January 15, 2010 to February 15, 2010.

Synopsis

The MOM program supports fundamental research on solid mechanics including theoretical, analytical, and computational approaches, model-based simulation, and the development of constitutive models.

Synopsis

Support is provided for participation and ocean drilling-related research performed by U.S. scientists.

Synopsis

Support is provided for research in biological oceanography.

Synopsis

Grants support research into the chemical components, reaction mechanisms, and geochemical pathways within the ocean and at its interfaces with the solid earth and the atmosphere.

Synopsis

Support is provided for research on a wide range of topics associated with the structure and movement of the ocean, with the way in which it transports various quantities, with the way the ocean's physical structure interacts with the biological and chemical processes within it, and with interactions between the ocean and the atmosphere, solid earth and ice that surround it.

Synopsis

Support is provided for research on all aspects of geology and geophysics of the ocean basins and margins, as well as the Great Lakes.

Deadline Note

Full proposal dates vary according to the program: Oceanographic Instrumentation - October 15, 2009; Ship Operations Program - November 1, 2009; Oceanographic Technical Services - November 15, 2009; Ocean Technology and Interdisciplinary Coordination - February 15, 2010. For the Ship Acquisition and Upgrade program and other Oceanographic Facility Activities, the program should be contacted directly.

Synopsis

The sponsor offers funding for construction, conversion, acquisition and operation of major shared-use oceanographic facilities.

Synopsis

The Oceanographic Technology and Interdisciplinary Coordination (OTIC) Program supports a broad range of research and technology development activities.

Deadline Note

Regular Grants are targeted for January 15, 2010. Proposals for Doctoral Dissertation Research Improvement Awards (DDRI) are due by October 15, 2009 and February 15, 2010.

Synopsis

The Geography and Regional Science (GRS) Program sponsors research on the geographic distributions and interactions of human, physical, and biotic systems on the Earth's surface.

Deadline Note

Proposals for Doctoral Dissertation Enhancement Projects may be submitted at any time. Proposals for International Research Experiences for Students may be submitted by September 15, annually, for activities for the subsequent summer, or by February 15, annually, for activities at other times.

Synopsis

The Developing Global Scientists and Engineers program provides highest quality international research experiences for U.S. students.

Deadline Note

The deadline for pre-proposals is February 15, 2010. Full proposals are due by April 5, 2010.

Synopsis

A -- 2010 TRANSPORTATION PLANNING BROAD AGENCY ANNOUNCEMENT (BAA) - 2010 TRANSPORTATION PLANNING BAA - ATTACHMENTS 1-3 SOL DTFH61-10-R-00013 POC Josph A. Fusari, Phone: 2023664244, Robert G Prior, Phone: 2023664247 WEB: FBO.govPermalink https://www.fbo.gov/spg/DOT/FHWA/OAM/DTFH61-10-R-00013/listing.html E-MAIL: Joseph.fusari@dot.gov, bob.prior@dot.gov Joseph.fusari@dot.gov, bob.prior@dot.gov NAICS: 541712 Attachment 3 - Past Performance Questionnaire Attachment 2 - Prime Contractors Analysis of Subcontractors Costs Attachment 1 - Sample Statement of Work 2010 Transportation Planning BAA BROAD AGENCY ANNOUNCEMENT (BAA) DTFH61-10-R-00013 January 2010 T A B L E O F C O N T E N T S Section Title Page 1 BAA Process Overview 3 2 Focus Areas 5 3 General Proposal Information 7 4 Instructions for Submission of Pre-Proposals 11 5 Pre-Proposal Content 11 6 Pre-Proposal Evaluation 12 7 Instructions for Full Proposals 12 8 Proposal Format 13 9 Evaluation Criteria 16 10 Technical and Cost Negotiations 20 11 Attachments 21 Section 1 BAA Process Overview 1.1 General Information CONTRACTING POINT OF CONTACT: Joseph Fusari Contract Specialist Joseph.Fusari@dot.gov 1.2 Summary of Important Dates This Broad Agency Announcement (BAA) describes a two-phase process forproposal submission and evaluation. In the first phase, short pre-proposals will be submitted for review. The Federal Highway Administration (FHWA) will then ask for full proposals of those pre-proposals that are of interest to FHWA. Further detail on proposal dates are as follows: The FHWA anticipates that the proposal, evaluation and award process for this BAA will proceed generally in accordance with the following schedule: BAA opens (FBO publication) January 5, 2009 Pre-Proposals Due 4:30 EST February 15, 2009 Invitation for Full Proposal March 5, 2009 Full Proposals Due 4:30 EST April 5, 2009 Anticipated Contract Award Date May 30, 2009 Proposals shall be sent by electronic transmission to: Joseph.Fusari@dot.gov. Any questions relating to this announcement must be emailed to the contracting point of contact. No telephonic requests will be taken. 1.3 Definitions Federal Acquisition Regulations (FAR) For additional information visit (http://farsite.hill.af.mil/vffara.htm) Metropolitan Planning Organization (MPO) The forum for cooperative transportation decision-making; required for urbanized areas with populations over 50,000. Office of Planning, Environment, and Realty For additional information visit ( http://www.fhwa.dot.gov/hep/index.htm ) Regional Planning Organization (RPO) A multipurpose organization composed of representativesof local governments and appointed representatives from the geographic area covered by the council, and designated as the primary organization to address problems and plan solutions that are of greater than local concern or scope Research Programs For additional information visit ( http://www.fhwa.dot.gov/hep/research.htm ) Safe, Accountable, Flexible, Efficient Transportation Equity Act: A Legacy for Users (SAFETEA-LU) For additional information visit ( http://www.fhwa.dot.gov/hep/step/index.htm ) 1.4 Background Section 5207 of the Safe, Accountable, Flexible, Efficient Transportation Equity Act: A Legacy for Users (SAFETEA-LU) established the Surface Transportation Environment and Planning Cooperative Research Program (STEP) authorizing funding to support this new program. The general objective of the STEP is to improve understanding of the complex relationship between surface transportation, planning and the environment. Section 5207 of SAFETEA-LU identifies certain characteristics of STEP regarding program contents and administration including: •· Develop more accurate models for evaluating transportation control measures and system designs for use by State and local governments to meet environmental requirements; •· Improve understanding of transportation demand factors; •· Develop indicators of economic, social, and environmental performance of transportation systems to facilitate alternatives analysis; •· Meet additional priorities determined through the transportation research and development strategic planning process identified in section 5208 of SAFETEA-LU; •· Refine the scope and research emphases through outreach and in consultation with stakeholders. Additional information on STEP including resources, research plans, focus areas, and proposal requests are located on page http://www.fhwa.dot.gov/hep/step/index.htm.1.5 Objectives and Description The FHWA, through the Office of Planning, Environment, and Realty is soliciting for proposals for research and development projects that could lead to transformational changes and revolutionary advances for transportation planning in the United States. The objective of this BAA is to advance the practice and application of transportation planning among state, metropolitan, regional, local, and tribal transportation planning governments in response to significant changes in the planning process and to identify new tools, techniques, and approaches that respond to national transportation planning priorities. 1.6 Program Scope The program scope is intentionally ambitious and broad to address the wide spectrum of topics and objectives that the funded investigations can support. This program is intended to spur innovation and focus on high risk and high pay-off research and development projects. Incremental advances, demonstrations of existing technologies or applications of state and metropolitan transportation planning activities are not within the scope of this program. Section 2 FOCUS AREAS 2.1 Focus Areas The FHWA is looking for projects within sevenfocus areas that are of particular strategic interest and relevance. Proposals in these areas are highly encouraged. These areas are consistent with emphasis areas identified for the Surface Transportation Environment and Planning Cooperative Research Program developed under Section 5207 of Safe, Accountable, Flexible, Efficient Transportation Equity Act: A Legacy for Users (SAFETEA-LU); see http://www.fhwa.dot.gov/hep/step/index.htm for more information. Additional information on the planning focus areas are located under the "Research Plans" heading located on page http://www.fhwa.dot.gov/hep/step/plans.htm. The seven focus areasinclude: (2.1.1) Tools and Techniques That Support State and local Planning Capacity Building The FHWA seeks to expand the knowledge, understanding, and implementation of efforts that will advance state and local planning capacity buildingincluding the consideration of audience needs, agency practices, and process requirements in statewide and metropolitan transportation planning. Key emerging planning research issues for State Departments of Transportation (DOT), Metropolitan Planning Organizations (MPO), and small and rural areas could consider: •§ How States, MPO, and Regional Planning Organizations (RPO) and benefit from livability, performance-based planning, asset management, and program cost management, •§ What new and innovative forecasting techniques are available through the development of new process or decision-support tools for planning that can be tailored to multi-use development, program finances and revenue,and coordination with new planning partners, •§ What emerging tools and techniques are available that would assist communities in maintaining their transportation system and more effectively prioritize and limited program resources, and •§ What jurisdictional and institutional issues exist, such asthe development of new planning tools that provide a framework for developing ashared vision for the future by analyzing various forces (e.g., health, transportation, economic, environmental, land use, etc.) that affect growth. •§ How jurisdictional and institutional issues including the development of new planning tools to provide a framework for developing a shared vision for the future by analyzing various forces (e.g., health, transportation, economic, environmental, land use, etc.) and their affects on each other to promote sustainable growth can be addressed. •§ How r egional and local impacts of transportation investments on various sustainability indicators (economy, environment, health, et cetera.) are considered in planning and project selection. (2.1.2) Tools and Techniques That Support Tribal Planning Capacity Building The FHWA seeks to expand the knowledge, understanding, and implementation of efforts that will advance the development of innovative tools or approaches that promote the integration of tribal issues into the transportation planning and programming processes at the State and metropolitan levels. Tribes are not required by law to develop or maintain transportation planning programs. This limits their ability to interface at the same level with States and metropolitan transportation planning and programming efforts minimizing their ability to interface through consultation efforts and their effectiveness when competing for State and metropolitan funding opportunities. Key emerging planning research issues are: •§ Development of "information tools" for Tribal Departments of Transportation can use to improve consultation practices in the statewide and metropolitan transportation planning processes, and •§ Identifying how innovative planning techniques can assist tribes in developing their own transportation planning program using novel processes that apply tools, techniques, and technology specifically designed for tribal transportation planning programs with limited staff and resources. (2.1.3) Global Climate Change and Air Quality Research needs should consider advancing the practice and application of transportation planning among state, regional, and local transportation planning agencies to successfully meet growing concerns about the relationship between transportation, air quality, and climate change. Key emerging research issues to consider include: •§ Howentities can better understand the contribution of transportation facilities and services to air pollution and greenhouse gases and their potential implications, including environmental and human health impacts, •§ How entities can develop and assess analytical methods to adequately identify and reduce transportation emissions that contribute to global climate change, •§ What cost-effective mitigation strategies are available to reduce transportation emissions that contribute to global climate change, •§ How can State DOT'simprove the understanding of climate change impacts on transportation facilities and systems and the ability to consider adaptation and mitigation, •§ How can State DOT's evaluate greenhouse gas mitigation efforts, •§ What new and innovative methods of communicating scientific and regulatory information on transportation-air quality to partners are available at State and localagencies and to stakeholders, and •§ How can State DOT's assess the potential impacts of climate change on transportation; and determine how to avoidand minimize potential climate change impacts during transportation system planning (2.1.4)Congestion Management Congestion Management Systems reflects a substantive shift in perspective and practice to address congestion management through a process that provides for effective management and operations an enhanced linkage to the planning process, and to the environmental review process, based oncooperatively developed travel demand reduction and operational management strategies as well as capacity increases. In support of the reduction of congestion on America's transportation network as well as support other initiatives to linkoperations and transportation planning, key emerging research issues to consider includes: •§ What innovations in congestion pricing and private sector involvement in transportation investment are available, •§ What advanced analysis tools are available for use in the measurement and evaluation of operational improvements and strategies in transportation planning and advance the Congestion Management Process, and •§ Whether new planning tools and programs for understanding, analyzing and responding to congestion problems are available. (2.1.5) Safety Planning Transportation safety planning should include the development and improvement of data collection methods and project selection processes that respond to the needs of planning and safety decision making processes and how helping planning agencies (State DOTs, MPOs, and Tribal Governments) can build their institutional capacity to integrate safety into their transportation planning and decision-making process. (2.1.6) Public Involvement, Environmental Justice, Visualization in Planning There is a continued need for assessing new methods in public involvement and community impact assessment practice. Environmental justice (including disabled and elderly which are 2 groups of individuals rapidly increasing in numbers) and visualization are emerging areas ofresearch and practice for transportation planning practitioners that can be utilized to help convey and obtain technical information with communities that traditionally were not involved in the planning process. Increasing awareness among State DOTs, MPOs, and other government agencies of the importance of ensuring civil rights and environmental justice in the transportation planning process would be beneficial where there is an opportunity to make trade-offs to avoid impacts. Similarity, visualization applied to transportation planning is an emerging area of both research and practice. Stakeholders from State DOTs, MPOs, and otherinterested parties would benefit from knowing how to effectively apply visualization and how it can result in applying new methods of communication between transportation practitioners, decision-makers, and the general public. (2.1.7) Freight Planning Freight movements are growing as a share of transportation system volumes. Key emerging research issues to consider includes: •§ How State DOTs can develop methods for the integration of freight into the transportation planning and programming processes at the State and metropolitan levels, •§ What innovative methods for effectively engaging the private sector freight community into the State and metropolitan planning processes; how parameterssuch as price, travel time, permitting, and user fees affect modal shift; what elasticities are inherent in these parameters; and new approaches for applying benefits/cost analyses of freight projects in the transportation planning process, and •§ How new planning tools and programs such as freight analytical techniques, freight modeling improvements, methods of innovative freight data collection and data sharing can be used. SECTION 3 GENERAL PROPOSAL INFORMATION 3.1 General Information All business and administrative correspondence or questions on this BAA should be directed to the contract specialist identified in section 1. The FHWA has budgeted approximately $1,500,000 for fiscal year 2010 to fund this research announcement. Proposals will be evaluated using a two-part process consisting of pre-proposals and full-proposals. Offerors whose pre-proposalsare of interest to the FHWA will be invited to submit full proposals. The FHWA may select for award all, none, or a subset of the acceptable proposals meeting its needs. The FHWA anticipates making multiple awards, typically of 12-24 months duration with the size of individual awards varying depending on the research area and study requirements. The FHWA strongly encourages cost sharing under anycontract that may result, and can offer cooperative agreements if the proposer can offer a cost share of 50 percent from non-federal sources of funding. The FHWA strongly encourages proposals that offer a significant non-federal matching funds or in-kind resources. Cost reasonableness and realism will also be considered in the overall selection process. Individual proposal evaluations will be based on acceptability or non-acceptability without regard to other proposals submitted under the announcement. Selection will be based primarily on scientific or technical merit, partnership, relevance and importance to agency, and the availability of funds. For cooperative agreements, the Federal share of the cost of a project or activity carried out under this program is limited by Section 5101(b)of SAFETEA-LU to fifty (50) percent, unless otherwise determined by the Secretary of Transportation. The number of awards, and their dollar value, will vary depending on the merit of proposals received and their potential to lead to transformational changes and advances in transportation planning practice. Offerors should prepare proposals with a baseline period of performance of 12-24 months and, if needed, with one or more options up to an additional 24-month period of performance. 3.2 Note: Not all technically meritorious proposals may be funded due to budgetary constraints. 3.3 Pre-Proposal and Full Proposal Process Proposals may respond to one or more of the focus areas but must indicate which area is primary and which area or areas are subordinate. Organizations also may submit morethan one proposal when the proposed effort includes multiple disparate objectives and tasks, covers multiple or disparate technologies areas, or would have a more supportable budget if provided in parts; however, each proposal will be considered independently. Proposals will be evaluated using a two-part process consisting of a pre-proposal and a full-proposal. The FHWA will evaluate pre-proposals against the evaluation criteria outlined below. Those offerors whose pre-proposals are of interest may be invited to submit a formal full-proposal. Offerors whose pre-proposals are determined not to be of interest are not precluded from submitting a full proposal and may do so if they desire. Approximately thirty (30) days after the pre-proposal submission deadline, offerors submitting pre-proposals will be contacted with a letter informing them either that the FHWA is requesting a formal cost and technical proposal or that the effort proposed is not of interest to the Government. 3.4 Other Administrative Information Proposals that plan to collect information from more than 9 non-Federal entities may require the FHWA to obtain clearance prior to the commencement of any information collection (Approximate time for clearance, 6 months). Awards involving any Privacy Act-covered data will require special clearances and protections. It is the policyof the FHWA to treat all proposals as competitive information and to disclose the contents only for the purposes of evaluation. Only Government evaluators willmake selections under this BAA. This announcement constitutes the public announcement as contemplated by FAR 6.102(d)(2), and no formal Request for Proposals or other solicitation regarding this announcement will be issued. Requests for same will be disregarded. 3.5 Deliverables The specific deliverables will depend upon the scope and objectives of the negotiated award. At a minimum, the contractor shall present results for at least one peer review and submit a final report,with a technical summary, that documents the research conducted in each task identified in the proposal. Additional deliverables such as interim reports, documentation, and instrumentation could be required and the specific deliverables will be identified in the negotiated statement of work. 3.6 Period of Performance The base contract period of performance is negotiable, but shall be no more than24 months from date of award. 3.7 Optional Future Phase or Phases Proposals mayinclude a discussion of work products for an optional, future phase or phases of work for up to an additional 24 months (up to three more pages). Such discussion shall be clearly labeled as "optional future phase or phases of work." The original phase or work shall in no way depend on work described under future phases in order to meet the program criteria. If a future phase or phases are included, a separate budget shall be included for the phase or phases and be labeled clearly as "separate budget for optional future phase or phases." 3.8 Pre-Proposaland Full Proposal Information The Government reserves the right to select for award any, all, part, or none of the proposals received in response to this announcement. In addition, the Government reserves the right to award either contracts, grants, or other instruments determined to be of benefit to the government inachieving the goals of this program. This BAA is an expression of interest onlyand does not commit the Government to pay any direct pre-proposal or proposal preparation costs. All responsible sources capable of satisfying the Government'sneeds may submit proposals, which will be evaluated. Historically Black Colleges and Universities (HBCU) and Minority Institutions (MI) are encouraged to submit proposals and join others in submitting proposals. However, no portion of thisBAA will be set aside for HBCU and MI participation due to the desire to solicit ideas as broadly as possible. The FHWA has budgeted approximately $1,500,000 to fund this research program. Proposals will be evaluated using a two-part process consisting of pre-proposals and full-proposals. Offerors whose pre-proposals are of interest to the FHWA will be invited to submit full proposals. The FHWA may select for award all, none, or a subset of the acceptable proposals to construct a balanced program meeting its needs. The FHWA anticipates making multiple awards from the $1,500,000, typically of an 16-18 month duration. Note: Awards with a total value (including full period of performance and any option periods) of $100,000 and below will be issued as purchase orders. Note: Awards over $100,000 will be issued as contracts or cooperative agreements. The FHWA strongly encourages cost sharing under any contract that may result, and can offer cooperative agreements if the proposer can offer a cost share of 50 percent or greater from non-federal sources of funding. For cooperative agreements, the Federal share of the cost of a project or activity carried out under this program is limited by Section 5101(b) of SAFETEA-LU to fifty (50) percent, unless otherwise determined by the Secretary of Transportation. The number of awards, and their dollar value, will vary depending on the merit of proposals received and their potential to lead to transformational changes and advances in transportation planning practice. Offerors should prepare proposals with a baseline period of performance of18 months and, if needed, with one or more options up to an additional 24-monthperiod of performance. The scope of this announcement is intentionally broad toinvite innovation and to provide the FHWA the flexibility to sponsor research that best addresses its objectives. In keeping with FHWA's desire for innovation and flexibility, the specific approach in the selected full proposals will vary and will be negotiated. Any resulting contracts will contain appropriate federalagency clauses for the type of procurement vehicle awarded. Prior to award, theOfferor shall be required to submit "Certifications and Representations." Data and reporting requirements will be negotiated with the offeror (s) selected for award(s). The proposal submission shall be conducted in two phases: •1. Pre-proposal for FHWA review •2. Full Proposal. Proposals may respond to one or more of the subject areas but must indicate which area is primary and which area or areas are subordinate. Organizations also may submit more than one proposal when the proposed effort includes multiple disparate objectives and tasks, covers multiple or disparate technologies areas, or would have a more supportable budget if provided in parts; however, each proposal will be considered independently. Proposals will be evaluated using a two-part process: pre-proposals and full-proposals. The FHWA will evaluate pre-proposals against the evaluation criteria outlined above. Those offerors whose pre-proposals are of interest may be invited to submit a formal full-proposal, as described below. Offerors whose pre-proposals are determined not to be of interest are not precluded from submitting a proposal and may do so if they desire. Approximately thirty (30) days after the pre-proposal submission deadline, offerors submitting pre-proposals will be contacted by the Technical Point of Contact with a letter informing them either thatthe FHWA is requesting a formal cost and technical proposal or that the effort proposed is not of interest to the Government. The FHWA strongly encourages proposals that offer a significant non-federal matching funds or in-kind resources. Good proposals will evidence strong internal backing with matching funds, innovative approaches in contracting and leveraging current and past technology development efforts that support this program. Such proposals will receive consideration in addition to and above how they respond to the technical criteria above. Cost reasonableness and realism will also be considered in the overall selection process. Individual proposal evaluations will be based on acceptability or non-acceptability without regard to other proposals submitted under the announcement. Selection will be based primarily on scientific or technical merit, partnership,relevance and importance to agency, and availability of funds. Section 4 4.1 Pre-Proposal Instructions Pre-proposals must be submitted via electronic mail and must be received on or before 4:30 PM (EST), February 15, 2010. Facsimile transmissions or hard copy transmissions of the pre-proposal will not be accepted; so any sent will be disregarded. Pre-proposals shall be submitted via email to: Joseph.Fusari@dot.gov. SECTION 5 CONTENT OF PRE-PROPOSALS 5.1 Content of Pre-Proposals Proposals should be submitted in Microsoft Word 2003 or Adobe Portable Document Format. The pre-proposals shall be no longer than 7 pages in length and include the following 7 sections: Page 1 shall include proposal information including (a) the Broad Agency Announcement Number, (b) project title, (c) name of organization, (d) name of principle investigator(s), (e) phone and addresses for bothtechnical and business contacts; and (f) the identification of the primary subject area and subordinate subject area or areas, if any, the proposal addresses. Pages 2 & 3 shall provide a brief statement of objectives, narrative to demonstrate an understanding of current practices, trends and future needs, and major intended tasks and proposed deliverables. Page 4 shall describe how the research would provide value to advancing practitioners involved in Statewide, metropolitan, rural, regional, local, or Tribal transportation planning. Page 5 shall describe how the research will respond to current or future needs in Statewide, metropolitan, rural, regional, local, or Tribal transportation planning. Page 6 shallintroduce the research team, their general qualifications and other resources to accomplish the proposed effort. Page 7 shall outline a draft budget (includingthe use of matching non-federal funds and resources, if applicable) The budget shall further include the anticipated period of performance and any anticipated option periods, and partnership/subcontractor structures. Offerors should refer to the Evaluation Criteria below to ensure that their pre-proposal addresses theFHWA's requirements. SECTION 6 EVALUATION CRITERIA OF PRE-PROPOSALS 6.1 Evaluation Criteria The primary basis for selecting pre-proposals will be technical merit, importance to the FHWA programs, and the availability of funds. Technical merit will be evaluated based on the following criteria, listed below in descending order of importance: Category I: Category I proposals are well-conceived, scientifically/ technically sound, pertinent to program goals/objectives, and offered by a responsible offeror. Category I proposals are recommended for full proposal (subject to availability of funds) and normally will be displaced only by other Category I proposals. Category II: Category II proposals are scientifically or technically sound that may require further development. They can be recommended for full proposal, but are a lower priority than Category I. Category III: Category III proposals are not technically sound or do not meet agency needs. Proposals in this category are not recommended for full proposal. SECTION 7 INSTRUCTIONS FOR SUBMISSION OF FULL PROPOSALS 7.1 Full Proposal Instructions After the pre-proposals evaluation stage is complete, offerors who are invited to submit full proposals will be notified of the actual dates for submission and will provided with specific instructions for submission of full proposals. Offerors who choose not to submit a pre-proposal, but who wish to submit a full proposal may do so, without invitation. It is presently anticipated that full proposals will include a technical proposal that is 20 pages or less in length, as well as a separate appropriate cost proposal. Offerors submitting full proposals will be asked to submit technical proposals that provide a refined research problem statement and work scope, a management plan, technology transition plan, staffing qualifications, and information regarding other ongoing research and work. In addition tothe technical proposal, offerors will be requested to submit a cost proposal that provides complete and detailed budget information (length as necessary), information on proposed cost sharing, and other general business information. If necessary, the FHWA will request additional cost back-up information, resumes or supplemental information as appropriate. Recipients of cooperative agreements willbe asked to complete the applicable SF-424series of forms Each Offeror shall submit their proposal electronically in Microsoft Office 2003 or equivalent formats. The evaluation board may take into account when making its evaluation, any failure to conform to the instructions and rules in this section or any attempt toevade these specifications and rules on the basis of technicalities, as indicators of future performance. If an Offeror does not understand the instructions asdescribed herein, then they must submit their questions(s) to the Contract Specialist (Joseph Fusari) for clarification sufficiently in advance of the deadlinefor the receipt of offers to get an answer in time to meet that deadline. 7.2 Questions on the BAA content, issues, or procedures should be emailed to: Joseph.Fusari@dot.gov. 7.3 Proposal Due Date Proposals are due by 4:30 pm EST on April 5, 20 10 electronically to: Joseph.Fusari@Dot.gov Offers must be received by thetime and due date specified herein to be considered timely and acceptable. SECTION 8 Proposal Format 8.1 Proposal Format Full proposals shall be submitted by an authorized representative and include a technical proposal 20 pages or less inlength, a separate cost proposal, resumes, and past performance. The technical proposal shall include the following four (4) sections and subsections: Part I Technical Proposal (1) Cover Page with (A) the BAA number, (B) proposal title, (C) type of business (large business, small disadvantaged business, other small business, HBCU or MI, other educational, or other nonprofit), (D) complete list ofsubcontractors, (E) technical and administrative points of contact including addresses, telephone numbers, electronic mail addresses, and facsimile machine numbers. (2) Refined research problem statement (up to three pages) with a description of the proposed visionary technology or system and how the proposed effort will meet the objectives of the broad agency announcement, a comparison of these innovative ideas with current approaches and the current state of the art and the expected impact of the research if successful. (3) Complete work scope (up to five pages) describing research methods, steps, schedule (for a period of performance up to two years) with milestones, expected deliverables and associated evaluation metrics for the proposed effort. (4) A Management Plan (no more than onepage) describing the overall approach to management of this effort, including abrief discussion of the proposed organization and the use of personnel and other resources. This section should also describe the partnership structure betweenthe entity proposing work and other public and private sector entities funding or otherwise substantially participating in the work, including State Departments of Transportation, State Air Quality Agencies, Metropolitan Planning Organizations, Universities, Foundations, etc. (5) A Technology Transition Plan (no more than one page) describing the how the research could be transferred into local or national practice. (6) Facilities: (no more than one page) describing the facilities that would be used for the proposed effort. (7) All work plans must include preparation of read-ahead documents, presentation materials, meeting facilities, and a two day presentation to a peer review panel of the base year validation results and plans for modeling scenarios implementation and scenario evaluation plans. In addition, at least one web conference will be subsequently held to respond to reviewer comments and present scenario evaluation findings. Members ofthe peer review will be identified in cooperation with FHWA. FHWA will arrange for peer travel and related expenses (8) The work plan shall clearly indicate how the proposed effort will lead to transformational changes and revolutionary advances for transportation planning. The work plan shall describe the necessary tasks required to support the proposed work. The work plan shall describe a timeline for completion of each task and the interrelationships of all tasks. Part II Staffing Proposal : (1) Research team qualifications (up to three pages) with title and identification of association to a specific project or functional group within the proposing organization or to a specific proposed subcontractor. Indicate the proposed amount of effort (person-hours) to be expended by each person during the proposed program. (2) As part of its proposal, the offeror shall designate a Project Manager and other personnel deemed by the offeror to be essential to the successful completionof the contract. These individuals will be listed in the contract as Key Personnel. In the event any of the Key Personnel are unable to perform as proposed forany reason during the performance of the contract, the contractor shall immediately notify the COTR and Contacting Officer in writing. Such notice will includean explanation of the problem, a proposed replacement by someone of equal or better qualifications and experience, and shall explain the impact on performance.All replacements are subject to the prior written approval of the Contracting Officer. However, the Government reserves the right to approve such replacements retroactively when circumstances prevent advance approval. Part III Past Performance/Experience (1) Reference to past relevant research at the national, state or regional level (up to two pages) describing capabilities, work, and significant accomplishments in areas associated with proposed research area or in closely related areas. Associate the described relevant experience to the specific project group or functional group in the proposing organization or to the specific proposed subcontractor(s). (2) Other proposals (one page maximum) summarizing current and pending proposals being executed or proposed to be executed with the support of personnel proposed in this effort. This list should include project scale, start and end dates, and the average amount of time planned or currently being expended on each effort. The list should be organized by names of the key personnel and other significant senior personnel. If none, state none under this section. (3) A Bibliography (one page maximum) of relevant technical papers and research notes which support the technical concepts and innovative ideas described in this proposal. Part IIII Cost Proposal (1) In addition to the above 20-page or shorter technical proposal, offerors shall submit a cost proposal that provides complete budget information (length as necessary). A separate summary budget shall be provided for the base period and for each proposed option period. Each summary budget shall include costs by each major cost category such as direct labor, fringe benefits, subcontracts, travel and other direct costs, overhead/indirect costs, and fee (if applicable). Direct labor information shall provide detail regarding each proposed individual or labor category, the number of hours or percent of time proposed for each period, and the unburdened hourly rate or salary for each person or category. For other direct costs (travel, materials and supplies, etc), provide detail and explanation for how each element of cost was derived and estimated. For any subcontracts, provide a separate detailed budget forthe subcontract work, and provide a price analysis of the work. Please note that the FHWA can pay per diem for travelers, but cannot pay for special meals or receptions under contracts. Only small printing/duplicating costs should be proposed, if needed; any large printing jobs must be carried out by the FHWA in accordance with Government Printing Office regulations. A separate detailed cost breakdown shall also be provided by task and subtask, using the same task or subtasknumbers as described in the scope of work in the technical proposal. If necessary, the government will request additional cost back-up information, resumes or supplemental information as appropriate. Details of any cost sharing to be undertaken by the offeror shall also be included in the cost section. Describe the type of funds (cash, in kind, etc.), and its contribution and relationship in enhancing the proposed effort. With the budget include the following mandatory business information regarding your company: Business Size; Federal Tax Identification Number (TIN); Dun & Bradstreet Number; Name and contact information (mail address, telephone, and email address) of your authorized business representative/point of contact. An SF1411, Contract Pricing Proposal Cover Sheet, is not required for this submission of your proposal. (2) An estimated budget and spending plan for completion of the project must be clearly labeled and identified in the cost proposal. 8.2 Subcontractors Subcontractors' proposals must be similarly structured. All subcontracted work must be properly identified as such. If a subcontractor elects to submit an abbreviated proposal, it is the offeror's responsibility to see that the subcontractor submits the information requested in paragraph 4(e)(1) or (2) above and submits the proposal directly to the Government's point of contact. The offeror must ensure that the subcontractor adheres to the guidance set forth herein. FAR 15.404-3 requires that the offeror provide an analysis of subcontractors' cost proposals. To that end, offeror's proposal must:(1) Identify principal items/services to be subcontracted. (2) Identify prospective subcontractors and the basis on which they were selected. If non-competitive, provide selected source justification (3) Identify the type of contractual business arrangement contemplated for the subcontract and provide a rationale for same. (4) Identify the basis for the subcontract costs (e.g., firm quote or engineering estimate, etc). (5) Identify the cost or pricing data or information other than cost or pricing data submitted by the subcontractor. (6) Provide an analysis of the proposed subcontract in accordance with FAR 15.404-3(b). Provide an analysis concerning the reasonableness, realism and completeness of each subcontractor's proposal. If the analysis is based on comparison with prior prices, identify the basis on which the prior prices were determined to be reasonable. The analysis should include, but not be limited to, an analysis of: materials, labor, travel, other direct costs and proposed profit or fee rates. A guide as to howthe analysis may be performed is located on Attachment No. 2. i. Changes to Pricing Proposals: Changes to previously submitted proposals must include documentation indicating how a previously submitted proposal is impacted or affected. (1)If changes to the original proposal are relatively insignificant and involve only minor changes to elements such as labor rates, overhead and General and Administrative (G&A) rates, bill of material changes, travel costs, and Other Direct Costs (ODC's), these change can be accomplished through the use of change pages or slip pages accompanied by new cost summaries. 8.3 NOTE: The requirements of Section 508 of the Rehabilitation Act may apply to certain deliverables under anyresulting award, including the final report. The applicability of Section 508 will be determined on a case-by-case basis depending on the nature of deliverables under each award that results from this BAA. 8.4 NOTE: Rights to copyrightablesoftware delivered under any resulting award of this BAA shall be determined inaccordance with 48 CFR 52.227-14 and alternatives I, II, III. Furthermore, all software deliveries, preliminary and final, will include as a minimum, well-documented source code in electronic readable format, overall software architecture documentation, overall and individual module interface documentation, and a users operations manual. All hardware deliveries will include all documentation necessary to reproduce (assemble) and operate the delivered hardware system(s). Also, if applicable, provide a summary of any proprietary claims to results, software, hardware, prototypes, or systems supporting and/or necessary for the use of the research, results, software, hardware, prototype, or system proposed for development under this broad agency announcement. If there are no proprietary claims, this section shall consist of a statement to that effect. SECTION 9 EVALUATIONCRITERIA OF FULL PROPORALS 9.1 Evaluation Criteria The primary basis for selecting proposals will be technical merit, importance to the FHWA programs, and the availability of funds. Technical merit will be evaluated based on the following criteria, listed in descending order of relative importance: Full proposals willbe evaluated based on the following criteria in descending order of importance below. 1. Technical Approach (55 points) •a. Provides a sound, feasible, and achievable technical approach. Discusses the steps (or tasks) to execute the methodology by which the project objective will be achieved (25 points) •b. Discusses and demonstrates the ability to clearly describe the project objectives, needs, and the manner in which they will be addressed. Te chnical approach issound, feasible, and achievable. (20 points) •c. Demonstrates a solid grasp of the subject area; familiarity with regulatory or programmatic issues. (10 points) 2. Staffing (45 points) •a. Includes the academic credentials, professional experience, subject matter expertise and technical competence of key personnel for this project, including all the personnel who will participate as subcontractors for this project (25 points) •b. Discusses the research team's relevant skills and experience that will ensure success. Provide a short bio andlist of relevant experience for each technical personnel. (15 points) •c. Provides contingency plans in place to replace key personnel over the life of the project without any adverse impact on performance (5 points) Evaluation Scale Outstanding Excellent Good Fair Poor Unsatisfactory 55 points 55 44 33 22 11 0 45 points 45 36 27 18 9 0 25 points 25 20 15 10 5 0 20 points 20 16 12 8 4 0 15 points 15 12 9 6 3 0 10 points 10 8 6 4 2 0 5 points 5 4 3 2 1 0 Outstanding - Very comprehensive, in-depth, clear response. The Proposal consistently meets thisstandard with no omissions. Consistently high quality performance can be expected. Excellent - Extensive, detailed response similar to outstanding in quality, but with minor areas of unevenness or spottiness. High quality performance is likely but not assured due to minor omissions or areas where less than excellent performance might be expected. Good - No deficiencies in the response. Better than acceptable performance can be expected, but in some significant areas, there is an unevenness or spottiness that might impact on performance. Fair - Deficiencies are confined to areas with minor impact on performance and can be corrected during negotiation without major revision to the proposal. Poor - Deficiencies exist in significant areas but can be corrected during negotiations without majorrevision to the proposal or serious deficiencies exist in areas with minor impact. Unsatisfactory - Serious deficiencies exist in significant areas. The proposal only indicates a willingness to perform without specifying how or demonstrating the capability to do so. Only vague indications of capability are present. 3. Past Performance •a. Demonstrated successful experience and examples in developing, deploying, and delivering improved and/or new tools, techniques, and procedures to support the project being proposed. •b. Includes examples of successful performance in prior contracts. The Government will evaluate the merits of each offeror's past performance based on its reputation with its former customers including some or allof the following past performance areas: (1) Quality of Service; (2) Timelinessof Performance; (3) Price/Cost Control; and (4) Customer Satisfaction. Evidencecan include references, samples of correspondence from satisfied clients, letters of recommendation, etc. In conducting the past performance evaluation, the Government may use information obtained from other sources. The Government may consider the currency, degree of relevance, source, and context of the past performance information it evaluates as well as general trends in performance, and demonstrated corrective actions. A significant achievement, problem/problem resolution, or lack of relevant data in any element can become an important consideration in the selection process. A negative finding in any element may result in an overall high-risk rating. The Government may also consider past performance information regarding predecessor companies, key personnel, other corporate entities or subcontractors where such information is relevant to this acquisition. Offerors' past performance will be rated as follows: Very Low Risk: Based on the offeror's past performance, very little doubt exists that the offeror will successfully perform the required effort. Low Risk: Based on the offeror's past performance, little doubt exists that the offeror will successfully perform the required effort. Moderate Risk: Based on the offeror's past performance, some doubt existsthat the offeror will successfully perform the required effort. High Risk: Based on the offeror's past performance, significant doubt exists that the offeror will successfully perform the required effort. Neutral Risk: The offeror has little or no recent/relevant past performance upon which to base a meaningful performance risk evaluation. The Government is not required to interview all points ofcontact identified by offerors. It is the responsibility of the offeror to provide complete past performance information and thorough explanations as required by Section L. The Government is not obliged to make another request for the required information. 9.2 Non-federal matching funds The FHWA strongly encourages proposals that offer a significant non-federal matching funds or in-kind resources. Good proposals will evidence strong internal backing with matching funds, innovative approaches in contracting and leveraging current and past technology development efforts that support this program. Such proposals will receive consideration in addition to and above how they respond to the technical criteria above. Cost reasonableness and realism will also be considered in the overall selectionprocess. Individual proposal evaluations will be based on acceptability or non-acceptability without regard to other proposals submitted under the announcement. Selection will be based primarily on scientific or technical merit, partnership, relevance and importance to agency, and availability of funds. Note that all technically meritorious proposals may not be funded due to budgetary constraints. In addition to the criteria listed above, cost/price will be considered in theaward decision. The proposals will be analyzed to assess their price reasonableness. This means that the prices in an offeror's proposal are realistic for the work to be performed, reflect a clear understanding of the requirements, and areconsistent with the various elements of the offeror's technical proposal. The Government will accept the offer that is considered the best value to the Government. A best value analysis will be performed taking into consideration the results of the technical evaluation, cost and past performance analysis, and the perceived ability to perform timely, high quality, consistently reliable support services as provided herein. In the determination of Best Value, the relative weight given to all evaluation factors other than price, when combined, is more important than price. However, offerors should note that as technical scores approachbeing essentially equivalent, cost would become more important in the selectiondecision. 9.3 Administrative Information It is the policy of the FHWA to treat all proposals as competitive information and to disclose the contents only for the purposes of evaluation. Only Government evaluators will make selections underthis BAA. This announcement constitutes the public announcement as contemplatedby FAR 6.102(d) (2), and no formal Request for Proposals or other solicitation regarding this announcement will be issued. Requests for same will be disregarded. The Government reserves the right to select for award any, all, part, or noneof the proposals received in response to this announcement. In addition, the Government reserves the right to award either contracts, purchase orders, or otherinstruments determined to be of benefit to the government in achieving the goals of this program. This BAA is an expression of interest only and does not commit the Government to pay any pre-proposal or proposal preparation costs. All responsible sources capable of satisfying the Government's needs may submit proposals, which will be evaluated. Historically Black Colleges and Universities (HBCU) and Minority Institutions (MI) are encouraged to submit proposals and join others in submitting proposals. However, no portion of this BAA will be set aside forHBCU and MI participation due to the desire to solicit ideas as broadly as possible SECTION 10 TECHNICAL AND COST NEGOTIATIONS 10.1 Contact Vehicle The Contract Officer will determine the appropriate award vehicle depending on the work to be performed and notify the offeror of his/her decision. 10.2 Model Proposal Once the proposal evaluation is completed and ranked, the offerors selected for negotiations are notified by letter, email or phone by the Contracting Officer. If necessary, this notification letter may include further instructions. The written notification shall also include a model contract. The model contract provides the basis for negotiations on all contractual requirements, terms, and conditions. If the offeror takes exception to any requirements, these must be specifically identified in the reply to the Contracting Officer. The reply must also include any other information required by the Government. 10.3 Revised or Updated CostProposal If necessary, at the same time an offeror is notified of their selection, they may be requested to submit either an updated or revised cost proposal and any additional cost information or backup cost data. 10.4 Technical Proposal Changes Normally, if any clarifications are needed by the Government technical evaluators, the offeror will be contacted before completion of the evaluation andreceipt of the notification letter. However, a proposal may be selected for negotiations although additional technical data is still required. If this occurs, the Government negotiator will request any technical documentation needed. 10.5 Buying Part versus All Normally an entire proposed effort is purchased; however,the FHWA may from time to time be interested in acquiring part or parts of a proposal. This is one reason the Government requires offerors to write the SOW in the form of separate tasks. It facilitates evaluation and provides an easy way to select desired tasks. If the FHWA decides to buy only part or parts of a proposal, the notification letter may request the offeror to revise the cost proposalto reflect only what will be purchased. SECTION 11 ATTACHMENTS 1•1. SampleStatement of Work •22. Prime Contractors Analysis of Subcontractors Costs •33. Past Performance Questionnaire CITE: https://www.fbo.gov/?s=opportunity&mode=form&id=ac164c8ae3c75df21e8786c2b9383d90&tab=core&_cview=0 Posted 01/05/10 (W-SN02034808). (0005)

Deadline Note

The deadline for receipt of optional letters of intent is February 15, 2010. The deadline for receipt of full applications is March 15, 2010.

Synopsis

The sponsor invites applications for the competing continuation of the Pediatric Acute Liver Failure Study Group. This FOA will utilize the NIH Cooperative Agreement (U01) grant mechanism.

Deadline Note

The deadline for receipt of optional letters of intent is February 15, 2010. The deadline for receipt of full applications is March 15, 2010.

Synopsis

The sponsor invites applications for the competing continuation of the Adult Acute Liver Failure Study Group. This FOA will utilize the NIH Cooperative Agreement (U01) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after February 16, 2010. The deadline for receipt of optional letters of intent is February 16, 2010. The deadline for receipt of full applications is March 15, 2010.

Synopsis

The sponsor invites projects that address research endeavors in specific areas that will benefit from significant three-year funds without the expectation of continued NIH funding beyond this period. The research supported by the program should have high short-term impact, and a high likelihood of enabling growth and investment in biomedical research and development, public health, and health care delivery. Applicants may propose to address either a specific disease- or technology-related research question relevant to the mission of one or more participating Institutes and Centers, or propose the creation of a unique infrastructure/resource designed to accelerate scientific progress in the future. All NIH Institutes and Centers with funding authority will participate with the NIH Office of the Director in this initiative. This FOA will be administered by the Office of the Director of the NIH (http://www.nih.gov). Awards will be administered by the participating Institutes and Centers. This FOA will utilize the NIH RC4 award mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after January 16, 2009. This program will expire on November 17, 2011.

Synopsis

The sponsor provides support for a wide variety of research designs in order to improve the quality, safety, effectiveness, and efficiency of health care through the implementation and use of health IT. These designs include: small pilot and feasibility or self-contained health IT research projects; secondary data analysis of health IT research; and economic (prospective or retrospective) analyses of health IT implementation and use. Through economic analyses estimates of health IT implementation and use costs and benefits will be generated. This program will use the NIH Small Research Grant (R03) award mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after January 16, 2009. This program will expire on November 17, 2011.

Synopsis

The sponsor provides support for short-term preparatory, pilot or feasibility studies that will inform larger scale real world health IT implementation and use or the conduct of more comprehensive health IT implementation research. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Synopsis

The Fairbanks District Mine Hazard Inventory will apply technical archaeological methods to systematically identify and inventory abandoned mine land hazards within the BLM’s Fairbanks District. This work will begin with a Class I literature and data review to determine and prioritize survey blocks. This will be followed by Class II sample and Class III intensive surveys of select blocks and drainages. The project will result in a final report containing a detailed account of the areas surveyed, the hazards identified, and their association with cultural resources. This final report will also contain the historic context necessary to determine if identified, archaeological sites that are eligible for inclusion in the National Register of Historic Places. This work will generate geospatial data that will be inserted in BLM and State of Alaska AML and Cultural Resources databases. It is anticipated that this work will create one fulltime professional job for the duration of the project, and at least 4 seasonal technician level positions. This work will also help jumpstart the aviation industry by involving use of aircraft with this project. Of equal importance, this project will address important legacy issues related to mining that have been largely unattended to for decades.

Synopsis

A -- ON-BOARD HYDROGEN STORAGE & POWER SYSTEMS FOR CLASS II FORKLIFTS (STOCK SELECTORS) SOL N0016410RGS57 DUE 021610 POC Lorna Tribby 812-854-6021 Lrna Tribby812-854-6021 lorna.tribby@navy.mil WEB: FBO.gov Permalink https://www.fbo.gov/spg/DON/NAVSEA/N00164/N0016410RGS57/listing.html E-MAIL: POINT OF CONTACT lorna.tribby@navy.mil NAICS: 541712 This synopsis is being posted to the Federal Business Opportunities (FBO) website located at http://www.fbo.gov, the NavyElectronic Commerce on Line (NECO) website located at https://www.neco.navy.mil/, and the Naval Surface Warfare Center, Crane Division, Acquisition website located at http://www.crane.navy.mil/acquisition/homepage.htm. FBO is the primary point of entry to be used when access to synopses and solicitations from the World Wide Web is required. However, the NECO webpage as well as the Naval Surface Warfare Center, Crane Division, Acquisition webpage serve as alternatives if the FBO website is unavailable. This requirement is for basic/applied R&D efforts for hydrogen storage and fuel cell system design concepts for operational demonstration. This endeavor will culminate one or more cost-type contract awards. The primary performance objective of this effort is to replace the current batteries in the battery powered fleet of Class II forklifts (stock selectors) operated atDefense Distribution Center Warner Robins, Georgia (DDWG) (30 total) with fuel cell powered units. The overarching objective of this program is to identify, design and complete a 12 month operational demonstration to validate fuel cell power units operationally and to significantly increase the Technology Readiness Levels (TRLs) and Manufacturing Readiness Levels (MRL's) associated with fuel cellpower system designs for DOD forklift applications. TRL and MRL definitions maybe found at: http://akss.dau.mil/dag/GuideBook/IG_c10.5.2.asp and https://acc.dau.mil/CommunityBrowser.aspx?id=18231 respectively. The secondary objective of this effort is to expand and improve the hydrogen infrastructure technologies used to support a fleet of stock selectors and other hydrogen powered equipment operated at DDWG. The current infrastructure that is being installed at DDWG is based on natural gas reforming at a centralized location at Robins AFB and then subsequently delivering, via mobile refueler, to six locations around the base where hydrogen powered equipment refill operations occur. Operations conducted utilizing this support infrastructure are limited by refill times when the mobile refueler is present at each of the refill locations. Proposals are requested to identify alternate solutions that will expand the existing hydrogen refill operational capabilities at select hydrogen refill locations. The third objective is to compile operational data to further support our ongoing development of the business case surrounding the use of hydrogen fuel cell powered material handling equipment in DOD warehousing operations. Contractors must be registered with the Central Contractor Registration database and have a Defense Contract Audit Agency approved accounting system. The Government intends to award to the responsible contractor(s) who offer the best value to the Government as described in the evaluation criteria listed in section M of the RFP. The solicitation will be available on or about 15 JAN 2010 at the following address: http://www.crane.navy.mil/acquisition/homepage.htm. It is the responsibility of interested vendors to monitor the Crane web site, FedBizOpps and/or NECO for amendments that may be issued to this solicitation. For changes made after the closing date, only those offerors that provide a proposal will be provided any changes/amendments and considered for future discussions and/or award. "No hard copies of the solicitation will be mailed". Interested sources must download from the www site listed. Offer must be submitted in the format specified in the solicitation. Questions should be directed to Ms. Lorna Tribby at telephone 812-854-6021 or email lorna.tribby@navy.mil (preferred method). All responsible sources may submit a proposal, which shall be considered. Please reference the above solicitation number when responding to this notice. CITE: https://www.fbo.gov/?s=opportunity&mode=form&id=079141b78d66feb55f947c64ee693069&tab=core&_cview=0 Posted 12/04/09 (W-SN02017364). (0338)

Synopsis

A -- KNOWLEDGE DISCOVERY AND DISSEMINATION (KDD) BROAD AGENCY ANNOUNCEMENT (BAA) - SOLICITATION / BROAD AGENCY ANNOUNCEMENT SOL IARPA-BAA-09-10(baa)POC Arthur Becker, WEB: FBO.gov Permalink https://www.fbo.gov/notices/cabb7f27cdc5ffa3f40aae8d81490602 E-MAIL: dni-iarpa-baa-09-10@ugov.gov dni-iarpa-baa-09-10@ugov.gov NAICS: 541712 Key Management Personnel Listing template in.doc format CERTIFICATE PERTAINING TO FOREIGN INTERESTS - SF328 Instructions document in.pdfformat CERTIFICATE PERTAINING TO FOREIGN INTERESTS - SF328 document in.pdf format Academic Institution Acknowledgement Letter in.doc format IARPA-BAA-09-10 Broad Agency Announcement in.pdf format Intelligence analysts must gather and analyze information from a wide variety of data sets that include: general references, news, technical journals and reports, geospatial data, entity databases, internal reports and more. The different terminologies, formats, data models, and contexts make it difficult to perform advanced analytic tasks across different datasets. If there are only a small, fixed number of data sets involved in an intelligence problem, then it may be practical to map all of the data sets to a common data model and to develop specialized analytic tools tailored to the problem. However, if the problem changes over time, the data sets are large or numerous, or there are new data sets that need to be integrated with those already in use,then a new approach is required. The focus of the KDD program is to develop novel approaches that will enable the intelligence analyst to effectively derive actionable intelligence from multiple, large, disparate sources of information, toinclude newly available data sets previously unknown to the analyst. The ability to quickly produce actionable intelligence from unanticipated, multiple, varied data sets require research advances in two key areas: (1) alignment of data models; and (2) advanced analytic algorithms. Making advances in these two research areas, and fully characterizing the performance of the research results using real Intelligence problems, is the focus of the IARPA Knowledge Discovery and Dissemination (KDD) Program. Performers shall perform research in both areas and develop prototype systems that implement their techniques and research results. The KDD Program will provide data sets to support research and development in addition to extensive test and evaluation. KDD test and evaluation will take place on an annual cycle, with each performer applying their prototype systems to challenge problems defined by the KDD Program. KDD evaluation of prototype systems will take place at government facilities and will use realistic Intelligence problems and real Intelligence data. The research supported by KDD will generally beunclassified, but the annual KDD evaluations will involve data sets classified no higher than SECRET//NOFORN. The KDD Program requires a combination of innovative research and the capability to develop robust prototypes. Research goals should be set, and research plans should be made, to take full advantage of the length of the KDD Program. The KDD Program expects a staged approach to prototype development; each successive prototype will leverage research progress made sincethe previous prototype. IARPA encourages teaming between academic and commercial entities to leverage the strengths of both types of organization. KDD requiresthe prime contractor for each performer team to have personnel and a facility cleared at the SECRET//NOFORN level at the time their proposal is submitted. KDD is planned as a 51-month program and anticipates making multiple awards. CITE: https://www.fbo.gov/?s=opportunity&mode=form&id=cabb7f27cdc5ffa3f40aae8d81490602&tab=core&_cview=0Posted 12/22/09 (W-SN02029103). (0356)

Synopsis

This program provides grants for capital improvements, and related infrastructure improvements at qualified shipyards that will be effective in fostering efficiency, competitive operations, and quality ship construction, repair, and reconfiguration.

Deadline Note

The due date for Step 1 proposals is February 16, 2010. The sponsor will invite successful applicants from the Step 1 process to submit a Step 2 proposal, which will be due on April 20, 2010.

Synopsis

The sponsor solicits ground-based proposals for the Space Radiation Program Element (SRPE) components of the Human Research Program (HRP). Proposals are solicited by the SRPE in the area of Space Radiation Biology utilizing beams of high energy heavy ions simulating space radiation at the NASA Space Radiation Laboratory (NSRL), at Brookhaven National Laboratory (BNL) in Upton, New York.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after May 16, 2009. The deadlines for receipt of standard R01 applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2012.

Synopsis

The sponsor invites grant applications for studies that focus on research to define factors affecting energy balance and to define mechanisms influencing cancer risk, prognosis, and quality of life. These studies may range from new analyses of existing datasets to additional collection of data and biological specimens in ongoing investigations. It is anticipated that the knowledge gained will provide additional information to better understand the relationships among energy balance, cancer risk, and prognosis. This FOA will use the NIH Research Project (R01) award mechanism.

Deadline Note

The deadlines for receipt of standard R01 applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on January 8, 2012.

Synopsis

The sponsor invites applications for research projects that investigate the effects of Erythropoietin (EPO) on tumor cell growth. EPO has been widely used to relieve the anemia associated with renal failure. In addition, EPO and other erythropoiesis stimulating agents (ESAs) have recently been used to treat the anemia associated with cancer chemotherapy. However, several clinical trials involving administration of ESAs, have suggested that ESAs may accelerate tumor progression and increase mortality in cancer patients. It is therefore important to understand the biology of ESAs on tumor cell growth and apoptosis. The purpose of this FOA is to stimulate high quality research on the effects of ESAs on tumor cell biology and tumor progression. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after September 16, 2009. The deadlines for receipt of standard R01 applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on September 8, 2012.

Synopsis

The sponsor invites research grant applications from institutions/organizations for the development and validation of biomarkers for: a) early detection, prediction of progression, and recurrence of hematopoietic malignancies, especially in high-risk individuals; and, b) for risk assessment of primary and secondary hematopoietic malignancies. This FOA is also encourages the development and improvement of specific technologies and methods for quantitative detection of novel biomarkers associated with hematopoietic malignancies. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after September 16, 2009. The deadlines for receipt of standard R01 applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on September 8, 2012.

Synopsis

The sponsor invites applications from institutions/organizations on the discovery and characterization of non-coding (nc) RNAs in preneoplasias and early stage cancers to: 1) improve early cancer detection, intervention, and prevention; 2) predict risk of progression from preneoplasia to cancer, and 3) distinguish benign lesions from precancerous lesions. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after May 16, 2009. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2012.

Synopsis

The sponsor invites grant applications for research entailing the use of health claims data for cancer surveillance. Cancer surveillance may include assessment of patterns of care, quality, and outcomes of care, and health disparities across the continuum of treatment. The objective of this FOA is to encourage R03 grant applications from individuals who are interested in carrying out small research projects that are designed to expand our understanding of the validity of and methods needed to use claims data for cancer surveillance. Responses to this FOA may also include pilot analyses needed to provide preliminary data for larger grant proposals. This program will use the NIH Small Research Grant (R03) award mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after May 16, 2009. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2012.

Synopsis

The sponsor invites grant applications for research entailing the use of health claims data for cancer surveillance. Cancer surveillance may include assessment of patterns of care, quality, and outcomes of care, and health disparities across the continuum of treatment. The objective of this Funding Opportunity Announcement (FOA) is to encourage R21 grant applications from individuals who are interested in carrying out exploratory/ developmental research projects that are designed to expand our understanding of the validity of and methods needed to use claims data for cancer surveillance. Responses to this FOA may also include pilot analyses needed to provide preliminary data for larger grant proposals. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after September 16, 2009. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on September 8, 2012.

Synopsis

The sponsors invite applications for clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, noncoding RNA, and other epigenetic processes involved in cancer prevention and development. Another important aim of this FOA is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after January 16, 2010. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on January 8, 2013.

Synopsis

The sponsor invites research applications that propose to evaluate profiles of methylation, histone modifications and micro RNA (miRNA) and their association with risk of developing cancer in different populations. The overarching goal of this FOA is to provide support for population based studies to define the role of epigenetic markers (methylation, histone and micro RNA profiles) changes to understand cancer etiology. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2011.

Synopsis

The sponsor offers support for research to: improve the measurement of racial /ethnic discrimination in health care delivery systems through improved instrumentation, data collection and statistical/analytical techniques; enhance understanding of the influence of racial/ethnic discrimination in health care delivery and its association with disparities in disease incidence, treatment and outcomes among disadvantaged racial/ethnic minority groups; and reduce the prevalence of racial/ethnic health disparities through the development of interventions to reduce the influence of racial/ethnic discrimination on health care delivery systems in the United States. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

This program will expire on September 8, 2011.

Synopsis

The sponsors offer support for individual-investigators or small groups to collaborate with the NIH Roadmap for Medical Research National Centers for Biomedical Computing (NCBCs). The intention of the collaborating projects is to engage researchers across the nation in building an excellent biomedical computing environment, using the computational tools and biological and behavioral application drivers of the funded NCBCs as foundation stones. This FOA is intended to support exploratory biomedical informatics and computational biology research—applications should be innovative, with high risk/high impact in new areas that are lacking preliminary data or development. This program will use the NIH Exploratory/Developmental (R21) grant mechanism. This PAR is developed as a Roadmap affiliated initiative.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after May 16, 2008. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2011.

Synopsis

The sponsor offers support for research that will enhance the understanding of the relationship between exposures to bioactive food components and/or environmental chemicals in utero , hormonal and growth factor response, gene expression or epigenetic changes and subsequent mammary cancer risk in preclinical models. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after January 16, 2009. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on January 8, 2012. Electronic application submission is required for this FOA. The new Adobe versions of the application forms are not yet available. Please check back in December to download the application package.

Synopsis

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after May 16, 2008. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2011.

Synopsis

The sponsor offers support the research on all aspects of stem cell biology, including research into the molecular and biochemical regulation of embryonic and adult stem cell behavior, with the goal of ultimately improving the specificity and long-term effectiveness of cancer therapy, through the targeting of those cells most responsible for disease progression and metastasis. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on November 6, 2011.

Synopsis

The sponsor offers support for projects that enhance the state-of-the-science on the causes of obesity and to inform Federal decision making on effective public health interventions for reducing the rate of obesity in the United States. This FOA is also intended to promote collaborative activities between researchers trained in economics and researchers specializing in public health, cancer, cardiovascular diseases, and other chronic diseases so that the desired goals can be more efficiently, quickly, and successfully attained. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2011.

Synopsis

The sponsor provides support for translational correlative studies that utilize annotated tumor and/or other biospecimens collected during large-scale multi-institutional clinical and/or prevention trials, respectively, with a goal to facilitate predictions of responses to current interventions, and inspire future development of improved therapeutic and preventive strategies. Projects proposed in response to this FOA should address the correlations between intervention outcomes and cancer patients’ disease characteristics determined at various cellular/molecular levels. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after May 16, 2008. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2011.

Synopsis

The sponsor offers support for research proposals focused on identifying protein biomarkers for cancers where etiology of the disease is attributed to infectious agents. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

This program will expire on January 8, 2011.

Synopsis

The sponsor offers support for research projects that will enhance understanding of human decision-making processes so that individuals can make more informed and satisfying choices regarding their health. The NCI encourages collaborations between basic judgment and decision-making researchers, and applied cancer control researchers that will elucidate single-event decision-making processes at the level of the individual patient or health care provider that are pertinent to cancer prevention, detection, treatment, survivorship, or end-of-life care. For the purpose of this initiative, a single-event decision is defined as a discrete decision made at a specific point in time. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after February 5, 2008. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2011.

Synopsis

The sponsor offers support for research to: improve the measurement of racial /ethnic discrimination in health care delivery systems through improved instrumentation, data collection and statistical/analytical techniques; enhance understanding of the influence of racial/ethnic discrimination in health care delivery and its association with disparities in disease incidence, treatment and outcomes among disadvantaged racial/ethnic minority groups; and reduce the prevalence of racial/ethnic health disparities through the development of interventions to reduce the influence of racial/ethnic discrimination on health care delivery systems in the United States. This program will use the NIH Small Research Grant (R03) award mechanism.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on January 8, 2011.

Synopsis

The sponsors offer support for research to critically evaluate the use of exfoliated cells to monitor the physiological effects of dietary bioactive food components thought to be involved with cancer prevention. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after May 16, 2009. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on March 6, 2009.

Synopsis

The sponsors applications that propose multidisciplinary research on potential reduced-exposure tobacco products, both smoked and smokeless. The multidisciplinary studies can span basic, biological, behavioral, surveillance, and epidemiology research. The tobacco industry is currently promoting several new products with claims that they: a) are less either harmful or less addictive; and b) purportedly deliver lower amounts of toxic, carcinogenic, and/or addictive agents to the user compared with conventional products. However, to date, the scientific evidence is insufficient to evaluate whether these new products actually reduce the users’ exposure or risk for tobacco-related diseases. The overarching goal of this FOA is to determine whether potential reduced-exposure tobacco products provide a truly, less-harmful alternative to conventional tobacco products, both at the individual and population level. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2009.

Synopsis

The sponsors offers support for Exploratory/Developmental Research Grant applications (R21) to investigate ethical issues in human subjects research. The purpose of this funding opportunity announcement is to solicit research addressing the ethical challenges of human subjects research in order to optimize the protection of human subjects and enhance the ethical conduct of human subjects research.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 2, May 1, and September 1 annually. This program will expire on September 8, 2010.

Synopsis

The sponsors offers support for research grant applications to investigate ethical issues in human subjects research. The purpose of this funding opportunity announcement is to solicit research addressing the ethical challenges of human subjects research in order to optimize the protection of human subjects and enhance the ethical conduct of human subjects research. This program will use the NIH Small Research Grant (R03) award mechanism.

Deadline Note

This program will expire on January 8, 2011.

Synopsis

The sponsors offers support aimed at enhancing nanoscience and nanotechnology research focused on problems in biology and medicine. Nanoscience and nanotechnology refer to research and development on the understanding and control of matter at a length scale of approximately 1 - 100 nanometers, where novel properties and functions occur because of the size. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after January 16, 2010. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on January 8, 2013.

Synopsis

The sponsor invites research applications from clinicians, epidemiologists, geneticists, statisticians, and translational researchers working in the field of cancer control and prevention to improve existing models for cancer risk and prognosis by developing innovative research projects that use existing data; develop new models for cancer risk and prognosis; and validate new models and evaluate their utility in research and clinic settings. To explore this opportunity, the NCI Division of Cancer Control and Population Sciences (DCCPS) and the Division of Cancer Treatment and Diagnosis (DCTD) encourage applications for research projects to develop, apply, and evaluate new and existing cancer risk and prognostic prediction models for use by researchers, clinicians, and the general public. This FOA is designed to provide a mechanism of support for investigators to address two major challenges in model development, which are: integrating diverse types of data (e.g., clinical, demographic, pathologic, environmental, epidemiologic, outcomes, and genetic data from varied data marts or warehouses); and ensuring adequate validation (i.e., using multiple separate populations to define sensitivity, specificity, and positive and negative predictive values). This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

This program will expire on March 17, 2010.

Synopsis

The sponsors provide support for exploratory/developmental nutrition and cancer prevention research. Specifically, this initiative seeks to promote cancer prevention research to identify and characterize molecular targets for bioactive food components. A bioactive food component is defined as a dietary constituent that has a health benefit by altering one or more cellular processes when provided in quantities over and beyond that needed for basic nutrition. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2011.

Synopsis

The sponsor provides support for research efforts aimed at establishing the physiological significance of dietary components in modulating the tumoricidal cell activity of natural killer (NK) cells for cancer prevention. The focus of research projects proposed in response to this FOA should be on defining the minimum quantity and duration of exposure to specific dietary components to modulate tumoricidal cell activity of NK cells for cancer prevention and the underlying mechanism(s) accounting for this response. Proposed projects must include animal and/or human investigations to be considered responsive to this announcement. Highly purified populations of immune cells, specific tumor cells such as RMA-S that lack class I MHC expression, target cell-free system, or single-cell assays may be used to define the molecular basis for the diet-induced changes in tumoricidal activity. However, the in vitro studies are only to be used to support in vivo studies and should not constitute the primary focus of the application. Molecular targets for food components may be examined at the sites of the tumoricidal cell receptors and cancer cell specific ligands, the output of tumoricidal cytokines (e.g., IFN-g), and the release of lytic granules such as a granulysin, perforin, and serine proteases (granzymes). This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

The deadlines for receipt of standard R21 applications under this announcement are: June 16, October 16, and February 16 annually. The deadlines for AIDS and AIDS-related applications are: May 7, September 7, and January 7 annually. This program will expire on May 8, 2011.

Synopsis

The purpose of the sponsor's program is to stimulate the development and validation of novel mitochondrial (mt) DNA biomarkers for early detection, diagnosis, prognosis, and risk assessment of cancer. This FOA will stimulate research on mutations in mtDNA for identification of additional indicators of tumor development and progression, including mitochondrial somatic mutations and mitochondrial haplogroups. This program will use the NIH Research Project (R21) award mechanism.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on September 8, 2011.

Synopsis

The sponsors provide support for hypothesis-driven projects exploring associations between the built environment, other contextual features of where people of all ages live and work and health behaviors related to energy balance. These projects should use population level data from health surveys and other large health studies. It is expected that the proposed projects will be designed to add/include contextual variables at diverse levels of geographic aggregation to such studies on behaviors that affect individual energy balance and thereby health. Subsequent analyses should be aimed at understanding the relative importance of the contextual variables (including home, work, school, and/or other environments) as determinants of energy balance-related health behaviors. Grant applications will be expected to use population level data from diverse sources for: 1) generation and addition of new geographic information system (GIS) data layers for analysis of contextual variables such as measures of the built and natural environments, to existing studies; 2) analyses of existing confidential geographic-based data either on site, at survey data centers, or other protected sites; and/or 3) merging multiple health-related data resources to allow new analyses of associations between contextual variables and energy balance-related health behaviors. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on September 8, 2011.

Synopsis

The sponsor provides support for research projects focused on the identification and characterization of diet-induced changes in inflammation linked to colon cancer risks. This FOA is designed to stimulate research efforts that will lead to the identification and characterization of: diet-induced changes in anti- and pro-inflammatory mediators that modulate colon cancer risk; b) genetic polymorphisms that modify the responses to specific bioactive food components with regard to colon cancer inhibition; and c) the physiological effectiveness of dietary components in terms of concentration, activity, duration of exposure, degrees of stability, chemical forms, and receptor-binding affinity in inflammatory colonocytes. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after January 16, 2009. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on September 8, 2012.

Synopsis

The sponsor provides support for applications from institutions and organizations that are interested in developing and testing innovative methods in cancer detection, diagnosis, and prognosis. The NCI is especially interested in research studies that focus on the development and testing of improved methods for detecting specific characteristics of cancer, which can be subsequently used for the clinical management of cancer patients or individuals who are at risk for (developing) cancer. It is important that research studies focus on the search for molecular and cellular differences between tumors, pre-malignant, or normal tissues. The studies should determine the clinical translational significance of these differences by correlation with clinical parameters, in order to answer clinical problems related to detection, diagnosis, treatment, and prognosis. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2010.

Synopsis

The sponsor solicits applications from organizations proposing to develop, characterize or improve animal models for human disease or to improve diagnosis and control diseases of laboratory animals that may interfere with research. Models to be considered must be applicable to the research interests of two or more categorical NIH Institutes/Centers. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after January 16, 2010. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on January 8, 2013.

Synopsis

The sponsor invites applications for large-scale clinical vision research projects, including randomized clinical trials and epidemiologic studies. At the time of submission, applications requesting support for these activities are expected to provide detailed information regarding the study’s rationale, design, analytic techniques, protocols and procedures, facilities and environment, organizational structure, and collaborative arrangements. This information is best conveyed in a well-documented Manual of Procedures (MOP), the development of which represents a costly and time-consuming activity. The Clinical Study Planning Grant is designed to facilitate activities central to the refinement of a study’s protocol and procedures and the development of a detailed MOP. The NEI Clinical Study Planning Grant may be used to support the development of a MOP, as well as to conduct preliminary studies to refine study procedures and/or assess recruitment potential. The Clinical Study Planning Grant is applicable to both epidemiologic and clinical trial research studies. This FOA will utilize the Clinical Study Planning Grant Program for Clinical Trials (R34) mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after September 16, 2009. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on September 8, 2012.

Synopsis

The sponsor invites applications from institutions/organizations that propose to conduct secondary data analyses utilizing existing database resources. Applications may be related to, but must be distinct from, the specific aims of the original data collection. The NEI supports an extensive portfolio of clinical trials and large-scale epidemiologic research projects, wherein numerous data collection activities are required to meet each project’s specific aims. The resultant wealth of data generated by these studies often provides unique, cost-effective opportunities to investigate additional research questions or develop new analytical approaches secondary to a project’s originally intended purpose. Data are not limited to that collected under NEI support but these data are of highest programmatic interest. The R21 may be used to develop new statistical methodologies or to test hypotheses using existing data. Applicants should consider the relevance of their proposed analyses to NEI programs and priorities as described in the “National Plan for Eye and Vision Research” available at http://www.nei.nih.gov. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2012.

Synopsis

The sponsors invites applications under the NIH Clinical Trial Planning Grant Program, the purpose of which is to provide support for the development of a Phase III clinical trial. This includes the establishment of the research team, the development of tools for data management and oversight of the research, the definition of recruitment strategies, and the finalization of the protocol and other essential elements of the study included in a manual of operations/procedures. The Clinical Trial Planning Grant is not designed for the collection of preliminary data or the conduct of pilot studies to support the rationale for a clinical trial. This FOA will utilize the Clinical Trial Planning Grant (R34) mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after September 5, 2009. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on September 8, 2012.

Synopsis

The sponsors invite applications that propose research on the roles of nutrition and physical activity in the development, prevention, and management of cardiovascular diseases (CVD) or pulmonary diseases. In particular, the FOA aims to (1) improve knowledge of the contribution of diet and physical activity to these conditions and how sleep influences these relationships, (2) increase the evidence base for refining public health recommendations and clinical guidelines regarding these lifestyle behaviors, and (3) develop and test strategies to improve the adoption of these recommendations. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after September 16, 2009. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on September 8, 2012.

Synopsis

The sponsor invites applications that propose to define the factors and mechanisms controlling the differentiation of embryonic or adult stem or progenitor cells, either in vitro or in vivo. It is designed to stimulate new scientific advances in stem cell differentiation including technology research that may not be hypothesis driven. The long range goal of this program is the development of methods to direct the differentiation or development of stem cells along specific cell lineages to yield replacement cells for clinical use, whether the replacement cells are formed in vitro for delivery or formed in vivo in the tissue or organ environment. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

This program will expire on January 8, 2011.

Synopsis

The sponsors provide support for applications from institutions/organizations that propose to study the ethical, legal and social implications (ELSI) of human genome research. This announcement is specifically designed to: 1) encourage the development of small, focused research projects by legal, historical, ethics, humanities, social sciences and behavioral scholars; 2) support exploratory studies that may provide preliminary findings or pilot data for larger research proposals; 3) support the secondary analysis of existing data; 4) support the development of new methodologies; and 5) stimulate and facilitate the entry of promising new investigators into ELSI Research. This program will use the NIH Small Research Grant (R03) award mechanism.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16 and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on January 8, 2011.

Synopsis

The sponsors provide support for innovative high risk/high payoff research related to genomics, including analysis of genome structure and function, genetic variation, population genomics, and ELSI (ethical, legal, and social implications). NHGRI places a high priority on research projects that address technology and methods development in all relevant areas, new approaches to bioinformatics that facilitate data management and data dissemination, new computational biology approaches to data analysis, new strategies to apply genomics to clinical problems, new approaches that combine genomics and population studies, and studies of the ethical, legal and social implications of genomics research including the exploration of new policy approaches to address social issues raised by new capabilities in genomics. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

This program expires September 8, 2012

Synopsis

The sponsor provides support for research related to occupational safety and health. Eligible applicants are domestic and foreign for-profit or non-profit organizations, public or private institutions, such as universities, colleges, hospitals, and laboratories, units of state and local governments, eligible agencies of the federal government, faith-based or community based organizations, and Indian Tribes, Tribal Government, and/or Organizations. The R21 award mechanism will be used.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after May 5, 2009. This FOA will expire on September 8, 2012.

Synopsis

The sponsor provides support for projects designed to develop an understanding of the risks and conditions that are associated with occupational diseases and injuries, to explore methods for reducing risks and for preventing or minimizing exposure to hazardous conditions in the workplace, and to translate significant scientific findings into prevention practices and products that will effectively reduce work-related illnesses and injuries. The R03 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. The R03 is intended to support small research projects that can be carried out in a short period of time with limited resources. This FOA will utilize the NIH Small Research Grant (R03) award mechanism,

Deadline Note

The deadline for receipt of optional letters of intent is one month prior to planned submission date. This program will expire on February 17, 2010.

Synopsis

The sponsors provide support for innovative exploratory/developmental investigations in primary immunodeficiency diseases focusing on ex vivo studies with human specimens and on studies with current or new animal models including novel clinical strategies for detecting, identifying the molecular basis of, or developing innovative therapies for primary immunodeficiency diseases. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

The deadline for receipt of optional letters of intent is one month prior to planned submission date. This program will expire on February 17, 2010.

Synopsis

The sponsors provide support for innovative exploratory/developmental investigations in primary immunodeficiency diseases focusing on ex vivo studies with human specimens and on studies with current or new animal models including novel clinical strategies for detecting, identifying the molecular basis of, or developing innovative therapies for primary immunodeficiency diseases. This program will use the NIH Small Research Grant (R03) award mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after September 5, 2008. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on September 8, 2011.

Synopsis

The sponsors provide support for research that will contribute to the overall understanding of vaccine safety. This research opportunity invites studies that address scientific areas potentially relevant to vaccine safety such as 1) physiological and immunological responses to vaccines and vaccine components, 2) how genetic variations affect immune/physiological responses that may impact vaccine safety, 3) identification of risk factors and biological markers that may be used to assess whether there is a relationship between certain diseases or disorders and licensed vaccines, 4) creation/evaluation of statistical methodologies for analyzing data on vaccine safety, including data available from existing data sources such as passive reporting systems, or 5) the application of genomic/molecular technologies to improve knowledge of vaccine safety. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on January 8, 2011.

Synopsis

The sponsors provide support for investigator-initiated research grant applications that seek to develop a comprehensive program of research focused on the mechanisms through which social, economic, cultural, and community-level factors, and their interactions, impact the early cognitive, neurobiological, socio-emotional, and physical development of children. This program will use the NIH Small Research Grant (R03) award mechanism.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 2, May 1, and September 1 annually. This program will expire on March 17, 2010.

Synopsis

The sponsor offers support for Small Research Grant (R03) applications from institutions/organizations that propose basic, clinical or translational research on the effects of the Fragile X pre-mutation on ovarian function, with a focus on premature ovarian failure or early menopause, in women and/or animal models. This program will use the NIH Small Research Grant (R03) award mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after January 16, 2008. This program will expire on January 8, 2011.

Synopsis

The sponsor provides support for applications from institutions/ organizations that propose to better understand the role of adipose tissue in the normal physiological regulation of reproduction, to discern its possible role in the etiology of diseases and disorders that impact human fertility, and to probe its potential importance in different racial/ethnic prevalence rates of certain reproductive disorders.This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after January 16, 2010. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on January 8, 2013.

Synopsis

The sponsor invites applications for research projects that involve secondary data analyses or development of statistical methodology using existing genome-wide data, relevant to human dental or craniofacial conditions or traits. This program will use the NIH Small Research Grant (R03) award mechanism.

Deadline Note

The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2010.

Synopsis

The sponsor provides support for applications that will use nonhuman primate models to study the oral biology of HIV infection and the oral complications associated with AIDS. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after May 16, 2008. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2011.

Synopsis

The sponsor provides support to conduct studies designed to develop innovative approaches that would contribute to understanding of the mechanisms that impact on the virulence of infections involving two or more microorganisms or strains of microorganisms (with the exception of HIV). This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

This program will expire on May 8, 2012, unless reissued.

Synopsis

The sponsor provides support for meritorious research projects that involve secondary data analyses using existing dental or craniofacial database resources. This program will use the Small Research Grant (R03) award mechanism.

Deadline Note

Applicants must obtain written approval from the NIDCR’s Director of the Division of Extramural Research (DER) or designee before submitting an R34 grant application. This letter must be included when submitting the R34 application. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on September 8, 2011.

Synopsis

The sponsor clinical trial planning (R34) grants for the comprehensive planning, design and documentation of investigator-initiated Phase I, II, III, or IV interventional clinical trials. Interventional behavioral studies, sometimes referred to as Stage I, II, III or IV studies, are included. The R34 planning grant is designed to: (1) permit early peer review of the rationale for the proposed clinical trial; (2) permit early assessment of the design and implementation plans of the proposed trial; and (3) provide support for the development of a comprehensive clinical trial protocol and associated documents including a Manual of Procedures. The complete protocol and associated documents are required components of any subsequent clinical trial implementation (U01) application. The product of the R34 will be either an application for a clinical trial implementation cooperative agreement (U01) or a report summarizing the work completed and the reasons for not proceeding to a clinical trial implementation application. This program will use the NIDCR Clinical Trial Planning (R34) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after May 16, 2009. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2012.

Synopsis

The sponsors invite applications to support the secondary analysis of existing data sets relevant to diabetes and endocrine and metabolic diseases; digestive diseases and nutrition, including obesity and eating disorders; and kidney, urologic, and hematologic diseases. The goal of this NIDDK program is to facilitate research that explores innovative hypotheses through the use of existing data sets. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after May 16, 2009. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2012.

Synopsis

The sponsors invite exploratory/developmental clinical research related to the prevention or treatment of diabetes, obesity and endocrine and genetic metabolic diseases. The Pilot and Feasibility Clinical Research Grants Program is designed to allow initiation of exploratory, short-term clinical studies, so that new ideas may be investigated without stringent requirements for preliminary data. The short-term studies should focus on research questions that are likely to have high clinical impact. They can include testing a new prevention strategy, a new intervention, or unique combinations of therapies. A high priority is the use of such studies to help stimulate the translation of promising research developments from the laboratory into clinical practice in diabetes, endocrine diseases and genetic metabolic diseases, including cystic fibrosis. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Synopsis

The sponsor requests applications for the Hispanic-Serving Institutions Education Grants Program (HSI) for fiscal year (FY) 2010 to promote and strengthen the ability of Hispanic-Serving Institutions to carry out higher education programs that attract, retain, and graduate outstanding students capable of enhancing the nation’s food, agricultural, and natural resource scientific and professional work force. NIFA anticipates the total amount available for support of the HSI in FY 2010 will be approximately $9.2 million.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after September 16, 2009. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on September 8, 2012.

Synopsis

The sponsors invites applications for research and developments in computational science and technology that will support rapid progress in areas of scientific opportunity in biomedical research. As defined here, biomedical computing or biomedical information science and technology includes database design, graphical interfaces, querying approaches, data retrieval, data visualization and manipulation, data integration through the development of integrated analytical tools, and tools for electronic collaboration, as well as computational and mathematical research including the development of structural, functional, integrative, and analytical models and simulations. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Synopsis

The sponsor is seeking applications for funding research and development to enhance forensic crime scene examinations and forensic medicolegal death investigations.

Deadline Note

The deadline to register with GMS and to submit applications is February 16, 2010.

Synopsis

The sponsor seeks proposals for research and development to enhance crime laboratories’ ability to identify, characterize, capture, visualize, and preserve impression evidence and pattern evidence.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after May 16, 2009. The deadlines for receipt of standard R21 applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2012.

Synopsis

The sponsor provides support for research on women's mental health in relation to pregnancy and the postpartum period. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after January 16, 2009. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on January 8, 2012.

Synopsis

The sponsors solicit collaborative preliminary intervention studies to evaluate the feasibility, tolerability, acceptability and safety of novel mechanism drug candidates, promising investigational new drugs (INDs), or novel psychosocial strategies for the treatment of mental disorders and for obtaining the preliminary data needed as a pre-requisite to larger-scale (efficacy or effectiveness) intervention or services studies. This FOA should be used when at least two but no more than three sites are needed to complete the study. The collaborating studies should be organized in order to increase sample size, accelerate recruitment, and/or increase sample diversity and representation. For a linked set of collaborative R34s, each site shall have its own Project Director/Principal Investigator and provide for a mechanism for cross-site coordination, quality control, database management, statistical analysis, and reporting. This FOA will utilize the NIMH Collaborative R34 award mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after May 16, 2009. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on May 8, 2012.

Synopsis

The sponsor provides support for research on women's mental health and sex/gender differences in mental health. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.

Deadline Note

Applications may be submitted to Grants.gov in response to this announcement on or after January 16, 2010. The deadlines for receipt of standard applications under this announcement are: February 16, June 16, and October 16 annually. The deadlines for receipt of AIDS-related applications are: January 7, May 7, and September 7 annually. This program will expire on January 8, 2013.

Synopsis

The sponsors invites research grant applications from organizations/institutions that propose the development of novel radioligands for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging in human brain, and that incorporate pilot or clinical feasibility evaluation in pre-clinical studies, model development, or clinical studies. This program will use the NIH Exploratory/Developmental (R21) grant mechanism.