Research Interests of Dr. John F. Marlier
Research Interest: Bioorganic Chemistry. Specifically, the use of isotope effects and other kinetic methods to investigate the mechanism of reactions of biochemical importance. To date most of the work is concentrated on acyl group reactions such are ester hydrolysis/aminolysis and amide hydrolysis.
Publications since 1990:
1. Marlier, J. F.; O'Leary, M. H. J. Am Chem. Soc., 1990, 112, 5996. "Carbon Kinetic Isotope Effects on the Hydrolysis of Aryl Carbonates."
2. Marlier, J. F. J. Am Chem. Soc., 1993, 115, 5953. "Heavy-Atom Isotope Effects on the Alkaline Hydrolysis of Methyl Formate: The Role of Hydroxide Ion in Ester Hydrolysis."
3. Marlier, J. F. "Kinetic Isotope Effects" in MacMillan Encyclopedia of Chemistry; Lagowski, J. J., Ed.; Vol. 3; MacMillan Reference, USA, Simon and Schuster MacMillan: New York, 1997, pp 824-826.
4. Marlier, J. F.; Haptonstall, B. A.; Johnson, A. J.; Sacksteder, K. A. J. Am Chem. Soc., 1997, 119, 8838.
5. Marlier, J. F.; Dopke, N. C.; Johnstone, K. R.; Wirdzig, T., A Heavy-Atom Isotope Effect Study of the Hydrolysis of Formamide" J. Am. Chem. Soc. 1999, 121, 4356-4363."
6. Marlier, J.F.; "Multiple Isotope Effects on the Acyl Group Transfer Reactions of Amides and Esters." Acc.Chem. Res. 2001, 34, 283-290.
7. Marlier, J. F.; Frey, T. G.; Mallory,
J. A.; Cleland, W. W.; “Multiple Isotope Effect Study of the Acid-Catalyzed
Hydrolysis of Methyl Formate” J. Org. Chem.; 2005;
70; 1737-1744. John F. Marlier, Professor
8. Marlier, J. F.; Campbell, E.; Lai, C.; Weber, M.; Reinhardt, L. A.; Cleland,
W. W. “Multiple Isotope Effect Study of the Acid-Catalyzed Hydrolysis of
Formamide”
J. Org. Chem.; 2006; 71; 3829-3836.
9. Marlier, J. F.; Cleland, W. W. “Multiple Isotope Effect Study of the
Hydrolysis of Formamide by Urease from Jack Bean (Canavalia ensiformis)”
Biochemistry; 2006;45;9940-9948.
Department of Chemistry and Biochemistry
Cal Poly State University
San Luis Obispo, CA 93407
email: jmarlier@calpoly.edu
voice: (805)756-1327